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Tbio
NDST3
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

Protein Summary
Description
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity. This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296499
  • ENSP00000296499
  • ENSG00000164100

Symbol
  • HSST3
  • HSST3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.71
microRNA
0.61
pathway
0.58
gene perturbation
0.56
tissue
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.36   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.36   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
2
3
2
5.5
41.8
self reported educational attainment
1
1
1
24.5
neuroticism measurement
1
2
0
5.6
24.3
childhood trauma measurement
1
1
1
2.5
1
1
0
1.1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
2
5.5
41.8
self reported educational attainment
1
24.5
neuroticism measurement
0
5.6
24.3
childhood trauma measurement
1
2.5
0
1.1
0.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-deacetylase and N-sulfotransferase 3
VGNC:48885
471290
Macaque
N-deacetylase and N-sulfotransferase 3
704244
Mouse
MGI:1932544
83398
Rat
RGD:1310960
295430
Dog
N-deacetylase and N-sulfotransferase 3
VGNC:43683
487918
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-deacetylase and N-sulfotransferase 3
Macaque
N-deacetylase and N-sulfotransferase 3
Mouse
Rat
Dog
N-deacetylase and N-sulfotransferase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95803-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
HS-GAG biosynthesis
Reactome
Heparan sulfate/heparin (HS-GAG) metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
HS-GAG biosynthesis
Heparan sulfate/heparin (HS-GAG) metabolism
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (46)
1 – 10 of 46
GPC4
Tbio
Novelty:  0.01319626
Score:  0.958
Data Source:  STRINGDB
GPC3
Tbio
Novelty:  0.00151823
Score:  0.953
Data Source:  STRINGDB
GPC2
Tbio
Novelty:  0.02182363
Score:  0.952
Data Source:  STRINGDB
GPC1
Tbio
Novelty:  0.00293087
Score:  0.952
Data Source:  STRINGDB
GPC5
Tbio
Novelty:  0.01257358
Score:  0.952
Data Source:  STRINGDB
GPC6
Tbio
Novelty:  0.01951872
Score:  0.951
Data Source:  STRINGDB
SDC2
Tbio
Novelty:  0.00597758
Score:  0.947
Data Source:  STRINGDB
SDC3
Tbio
Novelty:  0.01095269
Score:  0.943
Data Source:  STRINGDB
SDC4
Tbio
Novelty:  0.00319073
Score:  0.938
Data Source:  STRINGDB
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
Score:  0.932
Data Source:  STRINGDB
Publication Statistics
PubMed Score  10.36

PubMed score by year
PubTator Score  16.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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