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Tbio
STAU1
Double-stranded RNA-binding protein Staufen homolog 1

Protein Summary
Description
Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340954
  • ENSP00000345425
  • ENSG00000124214
  • ENST00000347458
  • ENSP00000323443
  • ENST00000360426
  • ENSP00000353604
  • ENST00000371802
  • ENSP00000360867
  • ENST00000371828
  • ENSP00000360893
  • ENST00000371856
  • ENSP00000360922

Symbol
  • STAU
  • STAU
  • PPP1R150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
interacting protein
0.98
virus perturbation
0.98
cellular component
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2429   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2429   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0