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Tbio
AP2A1
AP-2 complex subunit alpha-1

Protein Summary
Description
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to pl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354293
  • ENSP00000346246
  • ENSG00000196961
  • ENST00000359032
  • ENSP00000351926

Symbol
  • ADTAA
  • CLAPA1
  • ADTAA
  • CLAPA1
  • AP2-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein domain
1
drug perturbation
0.96
hub protein
0.96
transcription factor binding site profile
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.96   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.96   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
4
4
95.5
serum albumin measurement
1
4
4
92.1
urate measurement
2
2
4
71.8
Thyroid preparation use measurement
1
1
1
46.9
FEV/FEC ratio
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
4
95.5
serum albumin measurement
4
92.1
urate measurement
4
71.8
Thyroid preparation use measurement
1
46.9
FEV/FEC ratio
1
17.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 2 subunit alpha 1
VGNC:6614
468956
Macaque
adaptor related protein complex 2 alpha 1 subunit
719038
Mouse
MGI:101921
11771
Rat
RGD:1306254
308578
Dog
adaptor related protein complex 2 subunit alpha 1
VGNC:37958
484375
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 2 subunit alpha 1
Macaque
adaptor related protein complex 2 alpha 1 subunit
Mouse
Rat
Dog
adaptor related protein complex 2 subunit alpha 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95782-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (53)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 42
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Beta-catenin independent WNT signaling
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Beta-catenin independent WNT signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Gene Ontology Terms (31)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (330)
1 – 10 of 330
AP2S1
Tbio
Novelty:  0.01931502
p_int:  0.999997504
p_ni:  0.000002496
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999996626
p_ni:  0.000003374
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NECAP2
Tdark
Novelty:  0.4141034
p_int:  0.999981008
p_ni:  0.000018992
Score:  0.992
Data Source:  BioPlex,STRINGDB
CCDC32
Tdark
Novelty:  1.80929769
p_int:  0.999980077
p_ni:  0.000019923
Data Source:  BioPlex
AMPH
Tbio
Novelty:  0.00201043
p_int:  0.999910073
p_ni:  0.000089927
Score:  0.987
Data Source:  BioPlex,STRINGDB
EPS15L1
Tbio
Novelty:  0.06929299
p_int:  0.999899505
p_ni:  0.000100495
Score:  0.968
Data Source:  BioPlex,STRINGDB
ARFGAP1
Tbio
Family:  Enzyme
Novelty:  0.02654081
p_int:  0.999890554
p_ni:  0.000109446
Score:  0.934
Data Source:  BioPlex,STRINGDB
SNX9
Tbio
Novelty:  0.01737783
p_int:  0.999708002
p_ni:  0.000291998
Score:  0.911
Data Source:  BioPlex,STRINGDB
RUNDC3A
Tdark
Novelty:  0.23296904
p_int:  0.999440437
p_ni:  0.000559563
Score:  0.568
Data Source:  BioPlex,STRINGDB
AAGAB
Tbio
Novelty:  0.0479209
p_int:  0.999179348
p_ni:  0.000820652
Score:  0.407
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  11.96

PubMed score by year
PubTator Score  20.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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