Protein Summary
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100). The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is ...more
- ENST00000381434
- ENSP00000370842
- ENSG00000137033
- ENST00000417746
- ENSP00000394039
- ENST00000456383
- ENSP00000414238
- ENST00000611532
- ENSP00000478858
- C9orf26
- IL1F11
- NFHEV
- DVS27
- IL1F11
- NF-HEV
- NFEHEV
- C9orf26
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.98 | ||
biological term | 0.98 | ||
gene perturbation | 0.98 | ||
disease | 0.66 | ||
phenotype | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1939.43 (req: < 5)
Gene RIFs: 411 (req: <= 3)
Antibodies: 993 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1939.43 (req: >= 5)
Gene RIFs: 411 (req: > 3)
Antibodies: 993 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (176)
Nearest Tclin Targets
Pathways (20)
Reactome (14)
KEGG (4)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Deubiquitination | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-1 family signaling | ||||
Reactome | Interleukin-33 signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Deubiquitination | ||||
Immune System | ||||
Interleukin-1 family signaling | ||||
Interleukin-33 signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (1)
Components (5)
Processes (22)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (23)
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil percentage of leukocytes | 2 | 6 | 6 | 99.2 | |||||
15 | 12 | 1 | 1.2 | 99.1 | |||||
eosinophil count | 3 | 5 | 6 | 99 | |||||
childhood onset asthma | 4 | 4 | 0 | 1.2 | 97.8 | ||||
7 | 9 | 4 | 1.1 | 96.7 | |||||
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil percentage of leukocytes | 6 | 99.2 | |||||
1 | 1.2 | 99.1 | |||||
eosinophil count | 6 | 99 | |||||
childhood onset asthma | 0 | 1.2 | 97.8 | ||||
4 | 1.1 | 96.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 33 | VGNC:4763 | 737537 | |||||
Macaque | interleukin 33 | 717301 | ||||||
Mouse | MGI:1924375 | 77125 | ||||||
Rat | RGD:1311155 | 361749 | ||||||
Dog | interleukin 33 | VGNC:41982 | 403810 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 33 | |||||
Macaque | interleukin 33 | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 33 | |||||
Publication Statistics
PubMed Score 1939.43
PubMed score by year
PubTator Score 836.83
PubTator score by year
Related Publications
Text Mined References (425)
GeneRif Annotations (411)
Items per page:
0 of 0
PMID | Year | Title |
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