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Tbio
IL33
Interleukin-33

Protein Summary
Description
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100). The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381434
  • ENSP00000370842
  • ENSG00000137033
  • ENST00000417746
  • ENSP00000394039
  • ENST00000456383
  • ENSP00000414238
  • ENST00000611532
  • ENSP00000478858

Symbol
  • C9orf26
  • IL1F11
  • NFHEV
  • DVS27
  • IL1F11
  • NF-HEV
  • NFEHEV
  • C9orf26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
biological term
0.98
gene perturbation
0.98
disease
0.66
phenotype
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1939.43   (req: < 5)
Gene RIFs: 411   (req: <= 3)
Antibodies: 993   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1939.43   (req: >= 5)
Gene RIFs: 411   (req: > 3)
Antibodies: 993   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (176)
IL1RL1
Tbio
Novelty:  0.00541949
Score:  0.999
Data Source:  Reactome,STRINGDB
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.978
Data Source:  STRINGDB
USP21
Tbio
Family:  Enzyme
Novelty:  0.11434352
Score:  0.968
Data Source:  Reactome,STRINGDB
MYD88
Tbio
Novelty:  0.00037931
Score:  0.963
Data Source:  Reactome,STRINGDB
IRAK1
Tchem
Family:  Kinase
Novelty:  0.00170873
Score:  0.942
Data Source:  Reactome,STRINGDB
TRAF6
Tbio
Novelty:  0.00109366
Score:  0.942
Data Source:  Reactome,STRINGDB
IRAK4
Tchem
Family:  Kinase
Novelty:  0.00344058
Score:  0.939
Data Source:  Reactome,STRINGDB
TSLP
Tbio
Novelty:  0.00140333
Score:  0.934
Data Source:  STRINGDB
IL1RAP
Tclin
Novelty:  0.01115915
Score:  0.926
Data Source:  Reactome,STRINGDB
IL13
Tbio
Novelty:  0.00021435
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Deubiquitination
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-33 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Deubiquitination
Immune System
Interleukin-1 family signaling
Interleukin-33 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
6
6
99.2
15
12
1
1.2
99.1
eosinophil count
3
5
6
99
childhood onset asthma
4
4
0
1.2
97.8
7
9
4
1.1
96.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
6
99.2
1
1.2
99.1
eosinophil count
6
99
childhood onset asthma
0
1.2
97.8
4
1.1
96.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 33
VGNC:4763
737537
Macaque
interleukin 33
717301
Mouse
MGI:1924375
77125
Rat
RGD:1311155
361749
Dog
interleukin 33
VGNC:41982
403810
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 33
Macaque
interleukin 33
Mouse
Rat
Dog
interleukin 33
Publication Statistics
PubMed Score 1939.43
PubMed score by year
PubTator Score 836.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title