Tbio HSPA4L Heat shock 70 kDa protein 4L

Protein Summary

Description

Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• O95757
• A2ICT2
• Q4W5M5
• Q8IWA2

Gene Name

• HSPA4L

Ensembl ID

• ENST00000296464
• ENSP00000296464
• ENSG00000164070
• ENST00000508776
• ENSP00000422482

Symbol

• APG1
• OSP94
• APG-1
• HSPH3
• Osp94

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
gene perturbation	0.89
kinase perturbation	0.88
histone modification site profile	0.83
trait	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.55   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.55   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0