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Tbio
HSPA4L
Heat shock 70 kDa protein 4L

Protein Summary
Description
Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296464
  • ENSP00000296464
  • ENSG00000164070
  • ENST00000508776
  • ENSP00000422482

Symbol
  • APG1
  • OSP94
  • APG-1
  • HSPH3
  • Osp94
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
gene perturbation
0.89
kinase perturbation
0.88
histone modification site profile
0.83
trait
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.46   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.46   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
40.3
reticulocyte measurement
1
1
1
35
IGF-1 measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
40.3
reticulocyte measurement
1
35
IGF-1 measurement
1
33.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family A (Hsp70) member 4 like
VGNC:6423
742975
Macaque
heat shock protein family A (Hsp70) member 4 like
710143
Mouse
MGI:107422
18415
Rat
RGD:1306528
294993
Dog
heat shock protein family A (Hsp70) member 4 like
VGNC:54806
476089
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family A (Hsp70) member 4 like
Macaque
heat shock protein family A (Hsp70) member 4 like
Mouse
Rat
Dog
heat shock protein family A (Hsp70) member 4 like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95757-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Regulation of HSF1-mediated heat shock response
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Regulation of HSF1-mediated heat shock response
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (174)
1 – 10 of 174
TUSC2
Tbio
Novelty:  0.05958876
p_int:  0.983669254
p_ni:  0.016330746
Data Source:  BioPlex
DNAJB1
Tbio
Novelty:  0.00139956
Score:  0.987
Data Source:  STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
Score:  0.978
Data Source:  STRINGDB
HSPA12A
Tbio
Novelty:  0.11999085
Score:  0.976
Data Source:  STRINGDB
DNAJC2
Tbio
Family:  TF
Novelty:  0.01515066
Score:  0.974
Data Source:  STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
Score:  0.964
Data Source:  STRINGDB
DNAJB6
Tbio
Novelty:  0.01248367
Score:  0.952
Data Source:  STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
Score:  0.949
Data Source:  STRINGDB
DNAJC7
Tbio
Novelty:  0.02133191
Score:  0.948
Data Source:  STRINGDB
HSPA1L
Tbio
Novelty:  0.01658161
Score:  0.945
Data Source:  STRINGDB
Publication Statistics
PubMed Score  21.46

PubMed score by year
PubTator Score  12.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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