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Tbio
SEMA4F
Semaphorin-4F

Protein Summary
Description
Has growth cone collapse activity against retinal ganglion-cell axons. This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339773
  • ENSP00000342675
  • ENSG00000135622
  • ENST00000357877
  • ENSP00000350547

Symbol
  • SEMAM
  • SEMAW
  • S4F
  • SEMAM
  • SEMAW
  • M-SEMA
  • PRO2353
  • m-Sema-M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
disease perturbation
0.9
protein domain
0.85
histone modification site profile
0.79
virus perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.86   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.86   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
59.9
mean platelet volume
2
1
2
31.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
59.9
mean platelet volume
2
31.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ssemaphorin 4F
VGNC:6657
470411
Macaque
ssemaphorin 4F
710297
Mouse
MGI:1340055
20355
Rat
RGD:3658
29745
Dog
ssemaphorin 4F
VGNC:45997
483098
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ssemaphorin 4F
Macaque
ssemaphorin 4F
Mouse
Rat
Dog
ssemaphorin 4F
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95754-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (97)
1 – 10 of 97
TMPRSS11B
Tdark
Family:  Enzyme
Novelty:  1.20690443
p_int:  0.9981968
p_ni:  0.001803197
p_wrong:  2e-9
Data Source:  BioPlex
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.968264909
p_ni:  0.031704624
p_wrong:  0.000030467
Data Source:  BioPlex
ARSE
Tbio
Family:  Enzyme
Novelty:  0.00151862
p_int:  0.948283399
p_ni:  0.051716474
p_wrong:  1.27e-7
Data Source:  BioPlex
GRIA3
Tclin
Family:  IC
Novelty:  0.00584546
p_int:  0.948245937
p_ni:  0.051754063
Score:  0.177
Data Source:  BioPlex,STRINGDB
CD1E
Tbio
Novelty:  0.00171622
p_int:  0.940853291
p_ni:  0.059146674
p_wrong:  3.5e-8
Data Source:  BioPlex
USO1
Tbio
Novelty:  0.02066669
p_int:  0.922970943
p_ni:  0.077029057
Score:  0.183
Data Source:  BioPlex,STRINGDB
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.856041463
p_ni:  0.143958492
p_wrong:  4.5e-8
Data Source:  BioPlex
HLA-DRB1
Tchem
Novelty:  0.00240724
p_int:  0.843374394
p_ni:  0.156625606
Score:  0.163
Data Source:  BioPlex,STRINGDB
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.839548252
p_ni:  0.160440827
p_wrong:  0.000010921
Data Source:  BioPlex
TMEM106A
Tbio
Novelty:  0.32470607
p_int:  0.804201707
p_ni:  0.195798071
p_wrong:  2.22e-7
Data Source:  BioPlex
Publication Statistics
PubMed Score  133.86

PubMed score by year
PubTator Score  6.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer