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Tbio
FGF19
Fibroblast growth factor 19

Protein Summary
Description
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294312
  • ENSP00000294312
  • ENSG00000162344
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.82
cell type or tissue
0.76
gene perturbation
0.73
PubMedID
0.71
transcription factor binding site profile
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 365.27   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 409   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 365.27   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 19
VGNC:1054
747710
Mouse
MGI:1096383
14170
Rat
RGD:620166
170582
Dog
fibroblast growth factor 19
VGNC:40846
483681
Cow
fibroblast growth factor 19
VGNC:28975
521475
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 19
Mouse
Rat
Dog
fibroblast growth factor 19
Cow
fibroblast growth factor 19
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95750-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (65)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream signaling of activated FGFR4
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Downstream signaling of activated FGFR4
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (185)
1 – 10 of 185
FGFR4
Tclin
Family: Kinase
Novelty: 0.00258329
Score: 0.993
Data Source: Reactome,STRINGDB
FGFR2
Tclin
Family: Kinase
Novelty: 0.00066613
Score: 0.976
Data Source: STRINGDB
KLB
Tbio
Family: Enzyme
Novelty: 0.00446813
Score: 0.973
Data Source: Reactome,STRINGDB
FGFR3
Tclin
Family: Kinase
Novelty: 0.00071612
Score: 0.967
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.953
Data Source: Reactome,STRINGDB
FGFR1
Tclin
Family: Kinase
Novelty: 0.00055714
Score: 0.951
Data Source: STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.948
Data Source: Reactome,STRINGDB
FRS2
Tbio
Novelty: 0.00654052
Score: 0.946
Data Source: Reactome,STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.944
Data Source: Reactome,STRINGDB
FGF18
Tbio
Novelty: 0.00802997
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  365.27

PubMed score by year
PubTator Score  234.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer