GGPS1
Geranylgeranyl pyrophosphate synthase
Protein Summary
Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
- ENST00000282841
- ENSP00000282841
- ENSG00000152904
- ENST00000358966
- ENSP00000351852
- ENST00000391855
- ENSP00000375728
- ENST00000488594
- ENSP00000418690
- GGPPS
- GGPPS1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.96 | ||
virus perturbation | 0.85 | ||
histone modification site profile | 0.83 | ||
transcription factor binding site profile | 0.83 | ||
disease perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 356.46 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 408 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 356.46 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 408 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 54
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (54)
Protein-Protein Interactions (95)
MFAP5
Novelty: 0.01839035
p_int: 0.997307225
p_ni: 0.002692768
p_wrong: 7e-9
Data Source: BioPlex
TUSC1
Novelty: 0.12487295
p_int: 0.996405899
p_ni: 6.4e-8
p_wrong: 0.003594037
Score: 0.513
Data Source: BioPlex,STRINGDB
CCDC69
Novelty: 0.37983713
p_int: 0.991957379
p_ni: 0.008042585
p_wrong: 3.5e-8
Data Source: BioPlex
TULP3
Family: TF
Novelty: 0.06911636
p_int: 0.989476294
p_ni: 0.010523705
p_wrong: 1e-9
Data Source: BioPlex
IQGAP1
Family: Enzyme
Novelty: 0.00434481
p_int: 0.986207705
p_ni: 0.013792295
Data Source: BioPlex
FAM19A3
Novelty: 0.37183557
p_int: 0.97440392
p_ni: 0.02559608
p_wrong: 1e-9
Data Source: BioPlex
SLTM
Novelty: 0.09563037
p_int: 0.966329569
p_ni: 0.011082026
p_wrong: 0.022588405
Score: 0.239
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (17)
Reactome (6)
KEGG (2)
PathwayCommons (6)
UniProt (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of gene expression by SREBF (SREBP) | ||||
Reactome | Cholesterol biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of steroids | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of gene expression by SREBF (SREBP) | ||||
Cholesterol biosynthesis | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of steroids | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (5)
Components (1)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 4 | 3 | 4 | 87.3 | |||||
sex hormone-binding globulin measurement | 5 | 2 | 5 | 80.3 | |||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 68.3 | |||||
self reported educational attainment | 1 | 1 | 1 | 66.8 | |||||
2 | 1 | 2 | 49.5 | ||||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 4 | 87.3 | |||||
sex hormone-binding globulin measurement | 5 | 80.3 | |||||
monocyte percentage of leukocytes | 1 | 68.3 | |||||
self reported educational attainment | 1 | 66.8 | |||||
2 | 49.5 | ||||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | geranylgeranyl diphosphate synthase 1 | VGNC:1246 | 100610192 | |||||
Mouse | MGI:1341724 | 14593 | ||||||
Rat | RGD:1359680 | 291211 | ||||||
Dog | geranylgeranyl diphosphate synthase 1 | VGNC:41201 | 479198 | |||||
Horse | geranylgeranyl diphosphate synthase 1 | VGNC:18327 | 100050954 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | geranylgeranyl diphosphate synthase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | geranylgeranyl diphosphate synthase 1 | |||||
Horse | geranylgeranyl diphosphate synthase 1 | |||||
Publication Statistics
PubMed Score 356.46
PubMed score by year
PubTator Score 50.54
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
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