GGPS1
Geranylgeranyl pyrophosphate synthase
Protein Summary
Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
- ENST00000282841
- ENSP00000282841
- ENSG00000152904
- ENST00000358966
- ENSP00000351852
- ENST00000391855
- ENSP00000375728
- ENST00000488594
- ENSP00000418690
- GGPPS
- GGPPS1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.96 | ||
virus perturbation | 0.85 | ||
histone modification site profile | 0.83 | ||
transcription factor binding site profile | 0.83 | ||
disease perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 445.27 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 408 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 445.27 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 408 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 59
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0