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Tchem
GGPS1
Geranylgeranyl pyrophosphate synthase

Protein Summary
Description
Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282841
  • ENSP00000282841
  • ENSG00000152904
  • ENST00000358966
  • ENSP00000351852
  • ENST00000391855
  • ENSP00000375728
  • ENST00000488594
  • ENSP00000418690

Symbol
  • GGPPS
  • GGPPS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
virus perturbation
0.85
histone modification site profile
0.83
transcription factor binding site profile
0.83
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 356.46   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 408   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 356.46   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 54
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (54)
Minodronate
Rendered image for Minodronate
geranylgeranyl diphosphate
Rendered image for geranylgeranyl diphosphate
2E,6E-farnesyl bisphosphonate
Rendered image for 2E,6E-farnesyl bisphosphonate
BPH-252
Rendered image for BPH-252
BPH-715
Rendered image for BPH-715
CHEMBL4564934
Rendered image for CHEMBL4564934
3-azageranylgeranyl diphosphate
Rendered image for 3-azageranylgeranyl diphosphate
Protein-Protein Interactions (95)
CCL26
Tbio
Novelty:  0.00556498
p_int:  0.99952292
p_ni:  0.000477075
p_wrong:  5e-9
Data Source:  BioPlex
MFAP5
Tbio
Novelty:  0.01839035
p_int:  0.997307225
p_ni:  0.002692768
p_wrong:  7e-9
Data Source:  BioPlex
TUSC1
Tbio
Novelty:  0.12487295
p_int:  0.996405899
p_ni:  6.4e-8
p_wrong:  0.003594037
Score:  0.513
Data Source:  BioPlex,STRINGDB
IGF2
Tbio
Novelty:  0.00021277
p_int:  0.994446901
p_ni:  0.005553098
p_wrong:  2e-9
Data Source:  BioPlex
CCDC69
Tdark
Novelty:  0.37983713
p_int:  0.991957379
p_ni:  0.008042585
p_wrong:  3.5e-8
Data Source:  BioPlex
ODAPH
Tbio
Novelty:  0.20386223
p_int:  0.991773298
p_ni:  0.0082267
p_wrong:  2e-9
Data Source:  BioPlex
TULP3
Tbio
Family:  TF
Novelty:  0.06911636
p_int:  0.989476294
p_ni:  0.010523705
p_wrong:  1e-9
Data Source:  BioPlex
IQGAP1
Tbio
Family:  Enzyme
Novelty:  0.00434481
p_int:  0.986207705
p_ni:  0.013792295
Data Source:  BioPlex
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.97440392
p_ni:  0.02559608
p_wrong:  1e-9
Data Source:  BioPlex
SLTM
Tbio
Novelty:  0.09563037
p_int:  0.966329569
p_ni:  0.011082026
p_wrong:  0.022588405
Score:  0.239
Data Source:  BioPlex,STRINGDB
Pathways (17)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

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Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
3
4
87.3
sex hormone-binding globulin measurement
5
2
5
80.3
monocyte percentage of leukocytes
1
1
1
68.3
self reported educational attainment
1
1
1
66.8
2
1
2
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
87.3
sex hormone-binding globulin measurement
5
80.3
monocyte percentage of leukocytes
1
68.3
self reported educational attainment
1
66.8
2
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
geranylgeranyl diphosphate synthase 1
VGNC:1246
100610192
Mouse
MGI:1341724
14593
Rat
RGD:1359680
291211
Dog
geranylgeranyl diphosphate synthase 1
VGNC:41201
479198
Horse
geranylgeranyl diphosphate synthase 1
VGNC:18327
100050954
Species
Name
OMA
EggNOG
Inparanoid
Chimp
geranylgeranyl diphosphate synthase 1
Mouse
Rat
Dog
geranylgeranyl diphosphate synthase 1
Horse
geranylgeranyl diphosphate synthase 1
Publication Statistics
PubMed Score 356.46
PubMed score by year
PubTator Score 50.54
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title