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Tbio
OXSR1
Serine/threonine-protein kinase OSR1

Protein Summary
Description
Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311806
  • ENSP00000311713
  • ENSG00000172939

Symbol
  • KIAA1101
  • OSR1
  • OSR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.98
molecular function
0.98
virus perturbation
0.98
kinase perturbation
0.93


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.71   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 474   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.71   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 474   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
73
mean reticulocyte volume
1
1
1
45.9
mean corpuscular volume
1
1
1
42.5
reticulocyte measurement
1
1
1
9.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
73
mean reticulocyte volume
1
45.9
mean corpuscular volume
1
42.5
reticulocyte measurement
1
9.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
oxidative stress responsive 1
VGNC:2495
470791
Macaque
oxidative stress responsive 1
696362
Mouse
MGI:1917378
108737
Rat
RGD:1310466
316064
Dog
oxidative stress responsive 1
VGNC:44205
607809
Species
Name
OMA
EggNOG
Inparanoid
Chimp
oxidative stress responsive 1
Macaque
oxidative stress responsive 1
Mouse
Rat
Dog
oxidative stress responsive 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95747-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (56)
1 – 10 of 56
RELL1
Tbio
Novelty: 0.28949625
p_int: 0.999999928
p_ni: 7.2e-8
Score: 0.873
Data Source: BioPlex,STRINGDB
RELL2
Tbio
Novelty: 0.59290726
p_int: 0.999999327
p_ni: 6.73e-7
Score: 0.912
Data Source: BioPlex,STRINGDB
RELT
Tbio
Novelty: 0.07977949
p_int: 0.999993774
p_ni: 0.000006226
Score: 0.988
Data Source: BioPlex,STRINGDB
FGB
Tbio
Novelty: 0.00437751
p_int: 0.999259316
p_ni: 0.000740683
Data Source: BioPlex
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.996828
p_ni: 0.003172
Score: 0.217
Data Source: BioPlex,STRINGDB
ICMT
Tchem
Family: Enzyme
Novelty: 0.00706181
p_int: 0.866246125
p_ni: 0.133753875
Score: 0.199
Data Source: BioPlex,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.98
Data Source: STRINGDB
SLC22A13
Tbio
Family: Transporter
Novelty: 0.04702774
Score: 0.806
Data Source: STRINGDB
XYLB
Tbio
Family: Kinase
Novelty: 0.00540687
Score: 0.8
Data Source: STRINGDB
SLC22A14
Tdark
Family: Transporter
Novelty: 0.3340737
Score: 0.8
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.71

PubMed score by year
PubTator Score  7.47

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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