Protein Summary
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). This gene encodes a member of the copine family. Members of this family are calcium-dependent, phospholipid-binding proteins with C2 domains, two calcium- and phospholipid-binding domains. Through their domain structure and lipid binding capabilities, these proteins may play a role in membrane trafficking. This protein is thought to be brain-specific and has a domain structure of two N-terminal C2 domains and one von Willebrand factor A domain. It may have a role in synaptic plasticity. [provided by RefSeq, Jul 2013]
- ENST00000397016
- ENSP00000380211
- ENSG00000100884
- ENST00000537691
- ENSP00000440077
- ENST00000645359
- ENSP00000494138
- ENSG00000285221
- ENST00000647071
- ENSP00000494513
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.83 | ||
cell line | 0.49 | ||
metabolite | 0.49 | ||
molecular function | 0.49 | ||
cellular component | 0.44 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.15 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 154 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.15 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 154 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (94)
CPNE4
Novelty: 0.08077992
p_int: 0.999533156
p_wrong: 0.000466844
Score: 0.396
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Glycerophospholipid biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Phospholipid metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Glycerophospholipid biosynthesis | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Phospholipid metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (4)
Components (8)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 1 | 1 | 55.2 | ||||||
self reported educational attainment | 1 | 1 | 1 | 55.2 | ||||||
liver fat measurement | 1 | 1 | 1 | 48.5 | ||||||
liver fat measurement | 1 | 1 | 1 | 48.5 | ||||||
liver disease biomarker | 1 | 1 | 1 | 48.5 | ||||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 55.2 | |||||
self reported educational attainment | 1 | 55.2 | |||||
liver fat measurement | 1 | 48.5 | |||||
liver fat measurement | 1 | 48.5 | |||||
liver disease biomarker | 1 | 48.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | copine 6 | 100430623 | ||||||
Mouse | MGI:1334445 | 12891 | ||||||
Rat | RGD:1583895 | 691478 | ||||||
Dog | copine 6 | VGNC:39565 | 608275 | |||||
Horse | copine 6 | VGNC:16826 | 100054951 | |||||
Publication Statistics
PubMed Score 9.15
PubMed score by year
PubTator Score 5.50
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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