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Tbio
SNAP29
Synaptosomal-associated protein 29

Protein Summary
Description
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions. This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a signific ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215730
  • ENSP00000215730
  • ENSG00000099940

Symbol
  • CEDNIK
  • SNAP-29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.93
transcription factor perturbation
0.84
virus perturbation
0.83
cellular component
0.78
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.2   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.2   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (31)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Gene Ontology Terms (25)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (238)
1 – 10 of 238
STXBP5
Tbio
Novelty: 0.02221811
p_int: 0.999999851
p_ni: 1.48e-7
Score: 0.853
Data Source: BioPlex,STRINGDB
TRAF3
Tbio
Novelty: 0.00292884
p_int: 0.999999184
p_ni: 8.16e-7
Score: 0.237
Data Source: BioPlex,STRINGDB
SKA1
Tbio
Novelty: 0.02651071
p_int: 0.999998253
p_ni: 0.000001747
Score: 0.389
Data Source: BioPlex,STRINGDB
TRIM62
Tbio
Family: Enzyme
Novelty: 0.18733274
p_int: 0.999994885
p_ni: 0.000005111
p_wrong: 4e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
TRPM7
Tchem
Family: IC
Novelty: 0.00264253
p_int: 0.999957052
p_ni: 0.000042932
p_wrong: 1.6e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
TACC3
Tbio
Novelty: 0.00937929
p_int: 0.999831788
p_ni: 0.000168212
Data Source: BioPlex
EIPR1
Tbio
Novelty: 0.17162045
p_int: 0.999649095
p_ni: 0.000350905
Score: 0.768
Data Source: BioPlex,STRINGDB
VPS51
Tbio
Novelty: 0.04491738
p_int: 0.999512007
p_ni: 0.000487993
Score: 0.746
Data Source: BioPlex,STRINGDB
TRAF6
Tbio
Novelty: 0.00159491
p_int: 0.999500433
p_ni: 0.000499558
p_wrong: 9e-9
Score: 0.15
Data Source: BioPlex,STRINGDB
VPS50
Tdark
Novelty: 0.22423919
p_int: 0.999450479
p_ni: 0.000549521
Score: 0.822
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  39.20

PubMed score by year
PubTator Score  25.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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