You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
ESRRB
Steroid hormone receptor ERR2

Protein Summary
Description
Isoform 3: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (PubMed:17920186, PubMed:19755138). Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:23836911). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380887
  • ENSP00000370270
  • ENSG00000119715
  • ENST00000505752
  • ENSP00000423004
  • ENST00000509242
  • ENSP00000422488

Symbol
  • ERRB2
  • ESRL2
  • NR3B2
  • ERR2
  • ERRb
  • ESRL2
  • NR3B2
  • DFNB35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.92
transcription factor perturbation
0.74
biological process
0.72
PubMedID
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.66   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.66   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (11)
CHEMBL402491
Rendered image for CHEMBL402491
CHEMBL250097
Rendered image for CHEMBL250097
CHEMBL402492
Rendered image for CHEMBL402492
CHEMBL2326068
Rendered image for CHEMBL2326068
CHEMBL2326072
Rendered image for CHEMBL2326072
CHEMBL4071073
Rendered image for CHEMBL4071073
CHEMBL4100590
Rendered image for CHEMBL4100590
Protein-Protein Interactions (108)
POU5F1
Tbio
Family:  TF
Novelty:  0.00033974
Score:  0.924
Data Source:  STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
Score:  0.915
Data Source:  STRINGDB
NANOG
Tbio
Family:  TF
Novelty:  0.00054893
Score:  0.897
Data Source:  STRINGDB
NRIP1
Tbio
Novelty:  0.00551568
Score:  0.881
Data Source:  STRINGDB
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
Score:  0.839
Data Source:  STRINGDB
TFCP2L1
Tbio
Family:  TF
Novelty:  0.04097991
Score:  0.837
Data Source:  STRINGDB
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
Score:  0.818
Data Source:  STRINGDB
NCOA3
Tchem
Family:  Epigenetic
Novelty:  0.00193529
Score:  0.81
Data Source:  STRINGDB
NCOR2
Tchem
Family:  TF
Novelty:  0.00066449
Score:  0.807
Data Source:  STRINGDB
KLF4
Tbio
Family:  TF
Novelty:  0.00076828
Score:  0.796
Data Source:  STRINGDB
Pathways (73)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (36)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
9.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
9.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
estrogen related receptor beta
VGNC:12630
453056
Macaque
estrogen related receptor beta
703799
Mouse
MGI:1346832
26380
Rat
RGD:1359557
299210
Dog
estrogen related receptor beta
VGNC:40480
490798
Species
Name
OMA
EggNOG
Inparanoid
Chimp
estrogen related receptor beta
Macaque
estrogen related receptor beta
Mouse
Rat
Dog
estrogen related receptor beta
Publication Statistics
PubMed Score 152.66
PubMed score by year
PubTator Score 79.81
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title