Tbio HERC2 E3 ubiquitin-protein ligase HERC2

Protein Summary

Description

E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• O95714
• Q86SV7
• Q86SV8
• Q86SV9
• Q86YY3
• Q86YY4
• Q86YY5
• Q86YY6
• Q86YY7
• Q86YY8
• Q86YY9
• Q86YZ0
• Q86YZ1

Gene Name

• HERC2

Ensembl ID

• ENST00000261609
• ENSP00000261609
• ENSG00000128731

Symbol

• jdf2
• p528
• MRT38
• SHEP1
• D15F37S1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
ligand (protein) perturbation	0.83
kinase perturbation	0.81
molecular function	0.81
disease perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.21   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 47   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.21   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0