You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HERC2
E3 ubiquitin-protein ligase HERC2

Protein Summary
Description
E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
ligand (protein) perturbation
0.83
kinase perturbation
0.81
molecular function
0.81
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.35   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.35   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
10
6
3
2.2
99.5
eye color
3
1
1
18.1
97.8
skin pigmentation
2
2
2
97
puberty onset measurement
4
1
4
95.7
suntan
2
2
3
95.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
3
2.2
99.5
eye color
1
18.1
97.8
skin pigmentation
2
97
puberty onset measurement
4
95.7
suntan
3
95.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HECT and RLD domain containing E3 ubiquitin protein ligase 2
VGNC:11901
453257
Macaque
HECT and RLD domain containing E3 ubiquitin protein ligase 2
712294
Mouse
MGI:103234
15204
Rat
RGD:1307989
308669
Dog
E3 ubiquitin-protein ligase HERC2
479005
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HECT and RLD domain containing E3 ubiquitin protein ligase 2
Macaque
HECT and RLD domain containing E3 ubiquitin protein ligase 2
Mouse
Rat
Dog
E3 ubiquitin-protein ligase HERC2
Protein Structure (3 Structures, 19 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (28)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Cell Cycle
Cell Cycle Checkpoints
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (379)
1 – 10 of 379
PPL
Tbio
Novelty: 0.00684645
p_int: 0.999949234
p_ni: 0.000050766
Data Source: BioPlex
FBXL5
Tbio
Novelty: 0.03103624
p_int: 0.999948723
p_ni: 0.000051277
Score: 0.95
Data Source: BioPlex,STRINGDB
MAP7
Tbio
Novelty: 0.01976296
p_int: 0.999847449
p_ni: 0.000152551
Data Source: BioPlex
DBNL
Tbio
Novelty: 0.03390948
p_int: 0.999819286
p_ni: 0.000180714
Score: 0.174
Data Source: BioPlex,STRINGDB
MAP7D2
Tdark
Novelty: 0.70744439
p_int: 0.999816644
p_ni: 0.000183356
Data Source: BioPlex
CCDC136
Tbio
Novelty: 0.09279967
p_int: 0.999743369
p_ni: 0.000256631
Data Source: BioPlex
MAPK6
Tbio
Family: Kinase
Novelty: 0.01012514
p_int: 0.999392416
p_ni: 0.000607584
Score: 0.373
Data Source: BioPlex,STRINGDB
NCOA4
Tbio
Novelty: 0.00487453
p_int: 0.999383791
p_ni: 0.000616209
Score: 0.506
Data Source: BioPlex,STRINGDB
PRIMPOL
Tbio
Family: Enzyme
Novelty: 0.01285041
p_int: 0.999135313
p_ni: 0.000864687
Score: 0.191
Data Source: BioPlex,STRINGDB
ZNF286A
Tdark
Family: TF
Novelty: 3
p_int: 0.999122285
p_ni: 0.000877715
Data Source: BioPlex
Publication Statistics
PubMed Score  15.35

PubMed score by year
PubTator Score  50.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: