Tbio LY86 Lymphocyte antigen 86

Protein Summary

Description

May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity).

Uniprot Accession IDs

• O95711
• Q9UQC4
• Ly-86

Gene Name

• LY86

Ensembl ID

• ENST00000230568
• ENSP00000230568
• ENSG00000112799
• ENST00000379953
• ENSP00000369286

Symbol

• MD1
• MD1
• MD-1
• MMD-1
• dJ80N2.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.92
tissue sample	0.7
transcription factor perturbation	0.68
kinase perturbation	0.66
disease perturbation	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 462.57   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 341   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 462.57   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0