LY86
Lymphocyte antigen 86
Protein Summary
May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity).
- ENST00000230568
- ENSP00000230568
- ENSG00000112799
- ENST00000379953
- ENSP00000369286
- MD1
- MD1
- MD-1
- MMD-1
- dJ80N2.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.92 | ||
tissue sample | 0.7 | ||
transcription factor perturbation | 0.68 | ||
kinase perturbation | 0.66 | ||
disease perturbation | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 325.21 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 341 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 325.21 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 341 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (190)
VEGFB
Novelty: 0.00293322
p_int: 0.999636023
p_ni: 0.000041017
p_wrong: 0.00032296
Data Source: BioPlex
RAC3
Family: Enzyme
Novelty: 0.02125361
p_int: 0.999083264
p_ni: 0.000620223
p_wrong: 0.000296513
Data Source: BioPlex
CD55
Novelty: 0.0005689
p_int: 0.998055158
p_ni: 0.001831187
p_wrong: 0.000113654
Data Source: BioPlex
SPON1
Novelty: 0.01071398
p_int: 0.99760595
p_ni: 0.000222411
p_wrong: 0.002171638
Data Source: BioPlex
CTSF
Family: Enzyme
Novelty: 0.01359417
p_int: 0.99556122
p_ni: 0.004436875
p_wrong: 0.000001905
Data Source: BioPlex
DCP2
Family: Enzyme
Novelty: 0.00661786
p_int: 0.995506745
p_ni: 0.004492265
p_wrong: 9.9e-7
Data Source: BioPlex
SAMD1
Novelty: 0.21956379
p_int: 0.99515147
p_ni: 0.004848464
p_wrong: 6.7e-8
Data Source: BioPlex
PXYLP1
Family: Enzyme
Novelty: 0.04672634
p_int: 0.994850179
p_ni: 0.005148025
p_wrong: 0.000001796
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Toll Like Receptor 4 (TLR4) Cascade | ||||
Reactome | Toll-like Receptor Cascades | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Toll Like Receptor 4 (TLR4) Cascade | ||||
Toll-like Receptor Cascades | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Components (2)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 11 | 11 | 24 | 98.2 | |||||
waist-hip ratio | 7 | 9 | 12 | 96.2 | |||||
BMI-adjusted hip circumference | 3 | 11 | 13 | 95.6 | |||||
hip circumference | 3 | 8 | 8 | 94.4 | |||||
reticulocyte measurement | 3 | 2 | 3 | 75 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 24 | 98.2 | |||||
waist-hip ratio | 12 | 96.2 | |||||
BMI-adjusted hip circumference | 13 | 95.6 | |||||
hip circumference | 8 | 94.4 | |||||
reticulocyte measurement | 3 | 75 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lymphocyte antigen 86 | VGNC:12653 | 745667 | |||||
Mouse | MGI:1321404 | 17084 | ||||||
Rat | RGD:1309936 | 291359 | ||||||
Dog | lymphocyte antigen 86 | VGNC:42876 | 478712 | |||||
Horse | lymphocyte antigen 86 | VGNC:19846 | 100630498 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | lymphocyte antigen 86 | |||||
Mouse | ||||||
Rat | ||||||
Dog | lymphocyte antigen 86 | |||||
Horse | lymphocyte antigen 86 | |||||
Publication Statistics
PubMed Score 325.21
PubMed score by year
PubTator Score 6.70
PubTator score by year
Related Publications
Text Mined References (23)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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