You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
POP4
Ribonuclease P protein subunit p29

Protein Summary
Description
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P. This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000585603
  • ENSP00000465213
  • ENSG00000105171

Symbol
  • RPP29
  • RPP29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
disease perturbation
0.87
kinase perturbation
0.84
interacting protein
0.81
transcription factor binding site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.68   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.68   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (123)
C18orf21
Tdark
Novelty:  0.65363998
p_int:  0.999999999
p_ni:  1e-9
Score:  0.827
Data Source:  BioPlex,STRINGDB
RPP25
Tbio
Family:  Enzyme
Novelty:  0.07178063
p_int:  0.999999994
p_ni:  6e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
RPP30
Tbio
Family:  Enzyme
Novelty:  0.01375777
p_int:  0.999999059
p_ni:  9.41e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPP40
Tbio
Family:  Enzyme
Novelty:  0.05981624
p_int:  0.999992282
p_ni:  0.000007718
Score:  0.998
Data Source:  BioPlex,STRINGDB
RPP21
Tbio
Family:  Enzyme
Novelty:  0.05805689
p_int:  0.999970504
p_ni:  0.000029398
p_wrong:  9.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPP14
Tbio
Family:  Enzyme
Novelty:  0.10813341
p_int:  0.999967821
p_ni:  0.000020738
p_wrong:  0.000011441
Score:  0.998
Data Source:  BioPlex,STRINGDB
POP7
Tbio
Family:  Enzyme
Novelty:  0.05460002
p_int:  0.999962974
p_ni:  0.000037026
Score:  0.996
Data Source:  BioPlex,STRINGDB
RPP25L
Tdark
Family:  Enzyme
Novelty:  1.39761189
p_int:  0.999957167
p_ni:  0.000042832
p_wrong:  2e-9
Score:  0.984
Data Source:  BioPlex,STRINGDB
RPP38
Tbio
Family:  Enzyme
Novelty:  0.06387902
p_int:  0.999778165
p_ni:  0.000221835
Score:  0.999
Data Source:  BioPlex,STRINGDB
POP5
Tbio
Family:  Enzyme
Novelty:  0.02459167
p_int:  0.999749574
p_ni:  0.000094876
p_wrong:  0.000155551
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA processing
Reactome
tRNA processing in the nucleus
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA processing
tRNA processing in the nucleus
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to exercise
2
2
2
40.6
soluble triggering receptor expressed on myeloid cells 2 measurement
1
1
0
9196.5
24.5
heart rate response to recovery post exercise
2
1
2
7.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to exercise
2
40.6
soluble triggering receptor expressed on myeloid cells 2 measurement
0
9196.5
24.5
heart rate response to recovery post exercise
2
7.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
POP4 homolog, ribonuclease P/MRP subunit
VGNC:2282
456386
Macaque
POP4 homolog, ribonuclease P/MRP subunit
700209
Mouse
MGI:1913411
66161
Rat
RGD:1305955
292831
Dog
POP4 homolog, ribonuclease P/MRP subunit
VGNC:44816
612732
Species
Name
OMA
EggNOG
Inparanoid
Chimp
POP4 homolog, ribonuclease P/MRP subunit
Macaque
POP4 homolog, ribonuclease P/MRP subunit
Mouse
Rat
Dog
POP4 homolog, ribonuclease P/MRP subunit
Publication Statistics
PubMed Score 86.68
PubMed score by year
PubTator Score 32.99
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title