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Tbio
POP4
Ribonuclease P protein subunit p29

Protein Summary
Description
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P. This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000585603
  • ENSP00000465213
  • ENSG00000105171

Symbol
  • RPP29
  • RPP29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
disease perturbation
0.87
kinase perturbation
0.84
interacting protein
0.81
transcription factor binding site profile
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.36   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.36   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to exercise
2
2
2
42.5
heart rate response to recovery post exercise
2
1
2
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to exercise
2
42.5
heart rate response to recovery post exercise
2
3.9
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA processing
Reactome
tRNA processing in the nucleus
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA processing
tRNA processing in the nucleus
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (123)
1 – 10 of 123
C18orf21
Tdark
Novelty: 0.65363998
p_int: 0.999999999
p_ni: 1e-9
Score: 0.827
Data Source: BioPlex,STRINGDB
RPP25
Tbio
Family: Enzyme
Novelty: 0.07178063
p_int: 0.999999994
p_ni: 6e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
RPP30
Tbio
Family: Enzyme
Novelty: 0.01375777
p_int: 0.999999059
p_ni: 9.41e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
RPP40
Tbio
Family: Enzyme
Novelty: 0.05981624
p_int: 0.999992282
p_ni: 0.000007718
Score: 0.998
Data Source: BioPlex,STRINGDB
RPP21
Tbio
Family: Enzyme
Novelty: 0.05805689
p_int: 0.999970504
p_ni: 0.000029398
p_wrong: 9.8e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
RPP14
Tbio
Family: Enzyme
Novelty: 0.10813341
p_int: 0.999967821
p_ni: 0.000020738
p_wrong: 0.000011441
Score: 0.998
Data Source: BioPlex,STRINGDB
POP7
Tbio
Family: Enzyme
Novelty: 0.05460002
p_int: 0.999962974
p_ni: 0.000037026
Score: 0.996
Data Source: BioPlex,STRINGDB
RPP25L
Tdark
Family: Enzyme
Novelty: 1.39761189
p_int: 0.999957167
p_ni: 0.000042832
p_wrong: 2e-9
Score: 0.984
Data Source: BioPlex,STRINGDB
RPP38
Tbio
Family: Enzyme
Novelty: 0.06387902
p_int: 0.999778165
p_ni: 0.000221835
Score: 0.999
Data Source: BioPlex,STRINGDB
POP5
Tbio
Family: Enzyme
Novelty: 0.02459167
p_int: 0.999749574
p_ni: 0.000094876
p_wrong: 0.000155551
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  86.36

PubMed score by year
PubTator Score  32.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer