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Tchem
BRD1
Bromodomain-containing protein 1

Protein Summary
Description
Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216267
  • ENSP00000216267
  • ENSG00000100425
  • ENST00000404034
  • ENSP00000384076
  • ENST00000404760
  • ENSP00000385858
  • ENST00000457780
  • ENSP00000410042

Symbol
  • BRL
  • BRPF2
  • BRL
  • BRPF1
  • BRPF2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
protein domain
0.99
co-expressed gene
0.82
kinase perturbation
0.81
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.07   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.07   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
29.8
mean platelet volume
1
1
1
15.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
29.8
mean platelet volume
1
15.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bromodomain containing 1
VGNC:5231
470245
Macaque
bromodomain containing 1
715059
Mouse
MGI:1924161
223770
Rat
RGD:1311855
315210
Dog
bromodomain containing 1
VGNC:38518
481198
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bromodomain containing 1
Macaque
bromodomain containing 1
Mouse
Rat
Dog
bromodomain containing 1
Protein Structure (308 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95696-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 308
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
HATs acetylate histones
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (110)
1 – 10 of 110
KAT7
Tbio
Family: TF; Epigenetic
Novelty: 0.01783137
p_int: 0.99999629
p_ni: 8.8e-8
p_wrong: 0.000003622
Score: 0.995
Data Source: BioPlex,STRINGDB
KAT6B
Tbio
Family: Epigenetic
Novelty: 0.00361345
Score: 0.992
Data Source: STRINGDB
KAT6A
Tbio
Family: Epigenetic
Novelty: 0.00478771
Score: 0.989
Data Source: STRINGDB
MEAF6
Tbio
Novelty: 0.0914094
Score: 0.982
Data Source: STRINGDB
ING5
Tbio
Family: Epigenetic
Novelty: 0.03585867
Score: 0.969
Data Source: STRINGDB
CHD4
Tbio
Family: Epigenetic
Novelty: 0.00826969
Score: 0.939
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.928
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.927
Data Source: STRINGDB
CHD3
Tbio
Family: Epigenetic
Novelty: 0.00657278
Score: 0.925
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  174.07

PubMed score by year
PubTator Score  35.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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