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Tbio
FGFR1OP
FGFR1 oncogene partner

Protein Summary
Description
Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349556
  • ENSP00000230248
  • ENSG00000213066
  • ENST00000366847
  • ENSP00000355812

Symbol
  • FOP
  • FOP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
kinase perturbation
0.81
molecular function
0.81
biological process
0.77
pathway
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.31   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.31   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (197)
PPP2R3C
Tbio
Family:  Enzyme
Novelty:  0.02970644
p_int:  0.999999992
p_ni:  1e-9
p_wrong:  7e-9
Score:  0.857
Data Source:  BioPlex,STRINGDB
CEP350
Tbio
Novelty:  0.09063779
p_int:  0.999999991
p_ni:  7e-9
p_wrong:  2e-9
Score:  0.985
Data Source:  BioPlex,STRINGDB
MSL3
Tbio
Family:  Epigenetic
Novelty:  0.05711824
p_int:  0.999999937
p_ni:  6.2e-8
p_wrong:  1e-9
Score:  0.28
Data Source:  BioPlex,STRINGDB
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
p_int:  0.99948526
p_ni:  0.00051474
Score:  0.86
Data Source:  BioPlex,STRINGDB
CEP19
Tbio
Novelty:  0.20749222
p_int:  0.999452025
p_ni:  4.3e-8
p_wrong:  0.000547932
Score:  0.863
Data Source:  BioPlex,STRINGDB
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.999069791
p_ni:  0.000930173
p_wrong:  3.6e-8
Score:  0.163
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.998530909
p_ni:  0.001469091
Data Source:  BioPlex
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
p_int:  0.998514773
p_ni:  0.00148514
p_wrong:  8.7e-8
Score:  0.914
Data Source:  BioPlex,STRINGDB
RNF10
Tbio
Novelty:  0.09086567
p_int:  0.955387054
p_ni:  0.044612744
p_wrong:  2.02e-7
Data Source:  BioPlex
C7orf69
Tdark
Novelty:  13
p_int:  0.871026604
p_ni:  0.128973336
p_wrong:  6e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
5
5
1.2
98.9
4
4
0
1.2
96.3
2
2
0
1.2
92.8
autoimmune thyroid disease
1
1
0
1.1
87.8
3
2
1
1.1
83.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
1.2
98.9
0
1.2
96.3
0
1.2
92.8
autoimmune thyroid disease
0
1.1
87.8
1
1.1
83.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FGFR1 oncogene partner
VGNC:14366
472222
Macaque
FGFR1 oncogene partner
706749
Mouse
MGI:1922546
75296
Rat
RGD:1583370
683722
Dog
FGFR1 oncogene partner
VGNC:40857
612453
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FGFR1 oncogene partner
Macaque
FGFR1 oncogene partner
Mouse
Rat
Dog
FGFR1 oncogene partner
Publication Statistics
PubMed Score 13.31
PubMed score by year
PubTator Score 12.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title