Tbio FGFR1OP FGFR1 oncogene partner

Protein Summary

Description

Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O95684
• A8K1D1
• B2R705
• Q49AI0
• Q5R3F6
• Q96EW1

Gene Name

• FGFR1OP

Ensembl ID

• ENST00000349556
• ENSP00000230248
• ENSG00000213066
• ENST00000366847
• ENSP00000355812

Symbol

• FOP
• FOP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.83
kinase perturbation	0.81
molecular function	0.81
biological process	0.77
pathway	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.31   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 259   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.31   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0