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Tbio
KRT75
Keratin, type II cytoskeletal 75

Protein Summary
Description
Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle. This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS). [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252245
  • ENSP00000252245
  • ENSG00000170454

Symbol
  • K6HF
  • KB18
  • PFB
  • K6HF
  • KB18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.9
gene perturbation
0.69
cellular component
0.64
kinase perturbation
0.6
cell line
0.57


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.35   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.35   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
keratin 75
699682
Mouse
MGI:1923500
109052
Rat
RGD:1359576
300247
Dog
keratin 75
100683813
Horse
keratin 75
100061487
Species
Name
OMA
EggNOG
Inparanoid
Macaque
keratin 75
Mouse
Rat
Dog
keratin 75
Horse
keratin 75
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95678-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (67)
1 – 10 of 67
KRT16
Tbio
Novelty: 0.00503235
Score: 0.94
Data Source: STRINGDB
KRT17
Tbio
Novelty: 0.00278761
Score: 0.937
Data Source: STRINGDB
KRT14
Tbio
Novelty: 0.00088743
Score: 0.933
Data Source: STRINGDB
KRT15
Tbio
Novelty: 0.00351898
Score: 0.933
Data Source: STRINGDB
KRT36
Tdark
Novelty: 0.50578568
Score: 0.931
Data Source: STRINGDB
KRT35
Tbio
Novelty: 0.01111091
Score: 0.93
Data Source: STRINGDB
KRT34
Tbio
Novelty: 0.07747997
Score: 0.93
Data Source: STRINGDB
KRT32
Tdark
Novelty: 1.12077627
Score: 0.927
Data Source: STRINGDB
KRT28
Tdark
Novelty: 0.48119283
Score: 0.926
Data Source: STRINGDB
KRT25
Tbio
Novelty: 0.21822685
Score: 0.926
Data Source: STRINGDB
Publication Statistics
PubMed Score  86.35

PubMed score by year
PubTator Score  29.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer