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Tbio
CDS2
Phosphatidate cytidylyltransferase 2

Protein Summary
Description
Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000450570
  • ENSP00000403205
  • ENSG00000101290
  • ENST00000460006
  • ENSP00000419879
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.99
transcription factor binding site profile
0.84
ligand (protein) perturbation
0.83
metabolite
0.83


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.38   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.38   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDP-diacylglycerol synthase 2
VGNC:6075
469872
Macaque
CDP-diacylglycerol synthase 2
718026
Mouse
MGI:1332236
110911
Rat
RGD:621186
114101
Dog
CDP-diacylglycerol synthase 2
VGNC:39081
485780
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDP-diacylglycerol synthase 2
Macaque
CDP-diacylglycerol synthase 2
Mouse
Rat
Dog
CDP-diacylglycerol synthase 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95674-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PG
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PG
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (75)
1 – 10 of 75
CRLS1
Tbio
Family: Enzyme
Novelty: 0.08214782
Score: 0.973
Data Source: STRINGDB
CDIPT
Tbio
Family: Enzyme
Novelty: 0.00560887
Score: 0.973
Data Source: STRINGDB
TAMM41
Tbio
Family: Enzyme
Novelty: 0.06004824
Score: 0.969
Data Source: STRINGDB
AGPAT1
Tbio
Family: Enzyme
Novelty: 0.05245441
Score: 0.953
Data Source: STRINGDB
PGS1
Tbio
Family: Enzyme
Novelty: 0.09698838
Score: 0.948
Data Source: STRINGDB
MBOAT2
Tbio
Family: Enzyme
Novelty: 0.01820899
Score: 0.945
Data Source: STRINGDB
AGPAT3
Tbio
Family: Enzyme
Novelty: 0.06139822
Score: 0.944
Data Source: STRINGDB
AGPAT2
Tchem
Family: Enzyme
Novelty: 0.01321334
Score: 0.942
Data Source: STRINGDB
LCLAT1
Tbio
Family: Enzyme
Novelty: 0.03234576
Score: 0.942
Data Source: STRINGDB
PLD1
Tchem
Family: Enzyme
Novelty: 0.00608142
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.38

PubMed score by year
PubTator Score  20.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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