You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
NTSR2
Neurotensin receptor type 2

Protein Summary
Description
Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306928
  • ENSP00000303686
  • ENSG00000169006

Symbol
  • NTR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
gene perturbation
0.86
protein domain
0.58
virus perturbation
0.55
transcription factor binding site profile
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.69   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.69   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 33
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
levocabastine
chemical structure image
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurotensin receptor 2
VGNC:328
745294
Macaque
neurotensin receptor 2
697563
Mouse
MGI:108018
18217
Rat
RGD:70962
64636
Dog
neurotensin receptor 2
VGNC:44015
482972
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurotensin receptor 2
Macaque
neurotensin receptor 2
Mouse
Rat
Dog
neurotensin receptor 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95665-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (257)
1 – 10 of 257
NTS
Tbio
Novelty: 0.00033201
Score: 0.998
Data Source: Reactome,STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.963
Data Source: STRINGDB
CHRM1
Tclin
Family: GPCR
Novelty: 0.00427119
Score: 0.952
Data Source: STRINGDB
NMU
Tbio
Novelty: 0.00326109
Score: 0.95
Data Source: STRINGDB
GNG3
Tbio
Novelty: 0.16941216
Score: 0.946
Data Source: STRINGDB
GRM5
Tchem
Family: GPCR
Novelty: 0.00062552
Score: 0.945
Data Source: STRINGDB
TAC1
Tbio
Novelty: 0.00006575
Score: 0.943
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.939
Data Source: STRINGDB
GNG13
Tbio
Novelty: 0.13011919
Score: 0.939
Data Source: STRINGDB
GRM1
Tchem
Family: GPCR
Novelty: 0.00099764
Score: 0.936
Data Source: STRINGDB
Publication Statistics
PubMed Score  105.69

PubMed score by year
PubTator Score  26.82

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer