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Tbio
DIRAS3
GTP-binding protein Di-Ras3

Protein Summary
Description
This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370981
  • ENSP00000360020
  • ENSG00000162595
  • ENST00000646789
  • ENSP00000495736

Symbol
  • ARHI
  • NOEY2
  • RHOI
  • ARHI
  • NOEY2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
PubMedID
0.7
cell type or tissue
0.64
protein domain
0.58
gene perturbation
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.48   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.48   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
6
92.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
92.4
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DIRAS family GTPase 3
701273
Cow
DIRAS family GTPase 3
VGNC:28071
504559
Pig
DIRAS family GTPase 3
733668
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DIRAS family GTPase 3
Cow
DIRAS family GTPase 3
Pig
DIRAS family GTPase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95661-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (51)
1 – 10 of 51
SLC30A1
Tbio
Family:  Transporter
Novelty:  0.00528427
p_int:  0.997734111
p_ni:  0.002265889
Score:  0.209
Data Source:  BioPlex,STRINGDB
MTIF2
Tbio
Novelty:  0.06681774
p_int:  0.996370732
p_ni:  0.003629268
Score:  0.173
Data Source:  BioPlex,STRINGDB
FEZ2
Tbio
Novelty:  0.1716508
p_int:  0.986935851
p_ni:  0.012919706
p_wrong:  0.000144443
Score:  0.356
Data Source:  BioPlex,STRINGDB
RNF19B
Tbio
Family:  Enzyme
Novelty:  0.20054824
p_int:  0.917117447
p_ni:  0.082137021
p_wrong:  0.000745532
Score:  0.226
Data Source:  BioPlex,STRINGDB
DCAF10
Tdark
Novelty:  2.6713128
p_int:  0.870585076
p_ni:  0.129414924
Score:  0.237
Data Source:  BioPlex,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.735
Data Source:  STRINGDB
IARS
Tchem
Family:  Enzyme
Novelty:  0.00539046
Score:  0.666
Data Source:  STRINGDB
KDM4A
Tchem
Family:  Epigenetic
Novelty:  0.00643043
Score:  0.658
Data Source:  STRINGDB
PLAGL1
Tbio
Family:  TF
Novelty:  0.00845226
Score:  0.654
Data Source:  STRINGDB
NAP1L5
Tbio
Novelty:  0.10378595
Score:  0.647
Data Source:  STRINGDB
Publication Statistics
PubMed Score  102.48

PubMed score by year
PubTator Score  112.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer