Tchem NFATC1 Nuclear factor of activated T-cells, cytoplasmic 1

Protein Summary

Description

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O95644
• B5B2M4
• B5B2M5
• B5B2M6
• B5B2M7
• B5B2M8
• B5B2M9
• B5B2N1
• Q12865
• Q15793
• Q2M1S3
• NF-ATc1

Gene Name

• NFATC1

Ensembl ID

• ENST00000253506
• ENSP00000253506
• ENSG00000131196
• ENST00000318065
• ENSP00000316553
• ENST00000329101
• ENSP00000327850
• ENST00000397790
• ENSP00000380892
• ENST00000427363
• ENSP00000389377
• ENST00000542384
• ENSP00000442435
• ENST00000586434
• ENSP00000466489
• ENST00000591814
• ENSP00000466194
• ENST00000592223
• ENSP00000467181

Symbol

• NFAT2
• NFATC
• NFAT2
• NFATc
• NF-ATC
• NF-ATc1.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
PubMedID	0.97
protein domain	0.92
transcription factor perturbation	0.91
kinase	0.88

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Nuclear Factor Of Activated T-cells, Cytoplasmic 1

Protein / ... / Rel Homology Transcription Factor / Nuclear Factor Of Activated T-cells, Cytoplasmic 1

DTO Classes

Protein / Transcription Factor / Immunoglobulin Fold Transcription Factor / Rel Homology Transcription Factor / Nuclear Factor Of Activated T-cells, Cytoplasmic 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 862.91   (req: < 5)

Gene RIFs: 191   (req: <= 3)

Antibodies: 541   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 862.91   (req: >= 5)

Gene RIFs: 191   (req: > 3)

Antibodies: 541   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0