You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
NFATC1
Nuclear factor of activated T-cells, cytoplasmic 1

Protein Summary
Description
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253506
  • ENSP00000253506
  • ENSG00000131196
  • ENST00000318065
  • ENSP00000316553
  • ENST00000329101
  • ENSP00000327850
  • ENST00000397790
  • ENSP00000380892
  • ENST00000427363
  • ENSP00000389377
  • ENST00000542384
  • ENSP00000442435
  • ENST00000586434
  • ENSP00000466489
  • ENST00000591814
  • ENSP00000466194
  • ENST00000592223
  • ENSP00000467181

Symbol
  • NFAT2
  • NFATC
  • NFAT2
  • NFATc
  • NF-ATC
  • NF-ATc1.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
PubMedID
0.97
protein domain
0.92
transcription factor perturbation
0.91
kinase
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 862.91   (req: < 5)
Gene RIFs: 191   (req: <= 3)
Antibodies: 541   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 862.91   (req: >= 5)
Gene RIFs: 191   (req: > 3)
Antibodies: 541   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0