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Tbio
NFATC1
Nuclear factor of activated T-cells, cytoplasmic 1

Protein Summary
Description
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253506
  • ENSP00000253506
  • ENSG00000131196
  • ENST00000318065
  • ENSP00000316553
  • ENST00000329101
  • ENSP00000327850
  • ENST00000397790
  • ENSP00000380892
  • ENST00000427363
  • ENSP00000389377
  • ENST00000542384
  • ENSP00000442435
  • ENST00000586434
  • ENSP00000466489
  • ENST00000591814
  • ENSP00000466194
  • ENST00000592223
  • ENSP00000467181

Symbol
  • NFAT2
  • NFATC
  • NFAT2
  • NFATc
  • NF-ATC
  • NF-ATc1.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
PubMedID
0.97
protein domain
0.92
transcription factor perturbation
0.91
kinase
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 746.25   (req: < 5)
Gene RIFs: 135   (req: <= 3)
Antibodies: 541   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 746.25   (req: >= 5)
Gene RIFs: 135   (req: > 3)
Antibodies: 541   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
6
9
14
96.2
creatinine measurement
5
5
5
92.6
heel bone mineral density
3
3
5
91.6
mean platelet volume
3
6
6
90.3
lymphocyte count
2
2
2
77.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
14
96.2
creatinine measurement
5
92.6
heel bone mineral density
5
91.6
mean platelet volume
6
90.3
lymphocyte count
2
77.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear factor of activated T cells 1
VGNC:10017
455485
Macaque
nuclear factor of activated T-cells 1
698089
Mouse
MGI:102469
18018
Rat
RGD:2319357
100361818
Dog
nuclear factor of activated T cells 1
VGNC:43766
483925
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear factor of activated T cells 1
Macaque
nuclear factor of activated T-cells 1
Mouse
Rat
Dog
nuclear factor of activated T cells 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95644-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (61)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Beta-catenin independent WNT signaling
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) induces NFAT activation
Reactome
CLEC7A (Dectin-1) signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Beta-catenin independent WNT signaling
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) induces NFAT activation
CLEC7A (Dectin-1) signaling
Gene Ontology Terms (30)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (227)
1 – 10 of 227
PPP3CC
Tbio
Family: Enzyme
Novelty: 0.02633046
p_int: 1
Score: 0.984
Data Source: BioPlex,STRINGDB
HMGCS2
Tbio
Family: Enzyme
Novelty: 0.0103808
p_int: 0.999951148
p_ni: 0.000048852
Score: 0.309
Data Source: BioPlex,STRINGDB
PLOD1
Tbio
Family: Enzyme
Novelty: 0.00905345
p_int: 0.999846102
p_ni: 0.000153898
Data Source: BioPlex
PPP3R1
Tbio
Novelty: 0.00263264
p_int: 0.991175528
p_ni: 0.008824323
p_wrong: 1.48e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
OBSL1
Tbio
Novelty: 0.0325947
p_int: 0.984538502
p_ni: 0.015461498
Data Source: BioPlex
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.97766517
p_ni: 0.022268368
p_wrong: 0.000066463
Data Source: BioPlex
SEMA7A
Tbio
Novelty: 0.00741605
p_int: 0.969876149
p_ni: 0.030123121
p_wrong: 7.3e-7
Score: 0.239
Data Source: BioPlex,STRINGDB
ZMYND19
Tdark
Novelty: 0.3590069
p_int: 0.957737451
p_ni: 0.042178003
p_wrong: 0.000084546
Data Source: BioPlex
MKLN1
Tbio
Novelty: 0.05014385
p_int: 0.919838833
p_ni: 0.080161167
Data Source: BioPlex
LRRC28
Tdark
Novelty: 0.65377588
p_int: 0.881797199
p_ni: 0.000579306
p_wrong: 0.117623495
Score: 0.228
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  746.25

PubMed score by year
PubTator Score  357.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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