Tbio CPSF4 Cleavage and polyadenylation specificity factor subunit 4

Protein Summary

Description

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95639
• D6W5S8
• Q6FGE6
• Q86TF8
• Q9BTW6

Gene Name

• CPSF4

Ensembl ID

• ENST00000292476
• ENSP00000292476
• ENSG00000160917
• ENST00000436336
• ENSP00000395311

Symbol

• CPSF30
• NAR
• NEB1
• NAR
• NEB1
• NEB-1
• CPSF30

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
co-expressed gene	0.97
kinase perturbation	0.96
histone modification site profile	0.87
virus perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Endoribonuclease / Cleavage And Polyadenylation Specificity Factor Subunit 4

Protein / Nucleic Acid Binding / Rna Binding Protein / Endoribonuclease / Cleavage And Polyadenylation Specificity Factor Subunit 4

DTO Classes

Protein / Enzyme / Nuclease / Endoribonuclease / Cleavage And Polyadenylation Specificity Factor Subunit 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 638.78   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 199   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 638.78   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0