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Tbio
CPSF4
Cleavage and polyadenylation specificity factor subunit 4

Protein Summary
Description
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292476
  • ENSP00000292476
  • ENSG00000160917
  • ENST00000436336
  • ENSP00000395311

Symbol
  • CPSF30
  • NAR
  • NEB1
  • NAR
  • NEB1
  • NEB-1
  • CPSF30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
co-expressed gene
0.97
kinase perturbation
0.96
histone modification site profile
0.87
virus perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 492.93   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 492.93   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
dehydroepiandrosterone sulphate measurement
1
1
2
70.1
serum metabolite measurement
1
1
1
49.6
lymphocyte percentage of leukocytes
1
1
1
35.8
neutrophil percentage of leukocytes
1
1
1
34.5
smoking behavior
1
1
1
25.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
dehydroepiandrosterone sulphate measurement
2
70.1
serum metabolite measurement
1
49.6
lymphocyte percentage of leukocytes
1
35.8
neutrophil percentage of leukocytes
1
34.5
smoking behavior
1
25.3
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (24)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Host Interactions with Influenza Factors
Reactome
Infectious disease
Reactome
Influenza Infection
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Host Interactions with Influenza Factors
Infectious disease
Influenza Infection
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (299)
1 – 10 of 299
SMYD2
Tchem
Family: Epigenetic
Novelty: 0.0192516
p_int: 0.999999973
p_ni: 2.6e-8
p_wrong: 1e-9
Score: 0.217
Data Source: BioPlex,STRINGDB
WDR33
Tbio
Novelty: 0.09221439
p_int: 0.999999918
p_ni: 7.9e-8
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
P4HA1
Tchem
Family: Enzyme
Novelty: 0.01624726
p_int: 0.999999891
p_ni: 1.09e-7
p_wrong: 1e-9
Score: 0.33
Data Source: BioPlex,STRINGDB
KLK6
Tchem
Family: Enzyme
Novelty: 0.00488956
p_int: 0.999974435
p_ni: 0.000025565
Score: 0.19
Data Source: BioPlex,STRINGDB
SYMPK
Tbio
Novelty: 0.01773552
p_int: 0.999965065
p_ni: 0.000034933
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
FIP1L1
Tbio
Novelty: 0.00520044
p_int: 0.999943125
p_ni: 0.000056875
Score: 0.999
Data Source: BioPlex,STRINGDB
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.999849735
p_ni: 0.000042983
p_wrong: 0.000107282
Data Source: BioPlex
P4HA2
Tbio
Family: Enzyme
Novelty: 0.02097718
p_int: 0.999185911
p_ni: 0.000814045
p_wrong: 4.4e-8
Score: 0.265
Data Source: BioPlex,STRINGDB
AHCYL1
Tchem
Family: Enzyme
Novelty: 0.02176432
p_int: 0.998811423
p_ni: 0.001188568
p_wrong: 9e-9
Data Source: BioPlex
LZTS2
Tbio
Novelty: 0.09515452
p_int: 0.998623943
p_ni: 0.001372156
p_wrong: 0.000003901
Data Source: BioPlex
Publication Statistics
PubMed Score  492.93

PubMed score by year
PubTator Score  174.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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