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Tbio
NTN1
Netrin-1

Protein Summary
Description
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis. Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000173229
  • ENSP00000173229
  • ENSG00000065320

Symbol
  • NTN1L
  • MRMV4
  • NTN1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
virus perturbation
0.92
biological term
0.75
biological process
0.74
PubMedID
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 653.63   (req: < 5)
Gene RIFs: 113   (req: <= 3)
Antibodies: 317   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 653.63   (req: >= 5)
Gene RIFs: 113   (req: > 3)
Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
4
1
1.5
98.2
heel bone mineral density
3
2
5
95.7
Cleft palate
2
3
0
1.5
94.2
Oral cleft
2
2
1
1.4
86.6
neuroticism measurement
1
1
1
66.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.5
98.2
heel bone mineral density
5
95.7
Cleft palate
0
1.5
94.2
Oral cleft
1
1.4
86.6
neuroticism measurement
1
66.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
netrin 1
VGNC:9487
455083
Mouse
MGI:105088
18208
Rat
RGD:619809
114523
Dog
netrin 1
VGNC:44007
489497
Horse
netrin 1 [Source:HGNC Symbol;Acc:HGNC:8029]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
netrin 1
Mouse
Rat
Dog
netrin 1
Horse
netrin 1 [Source:HGNC Symbol;Acc:HGNC:8029]
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95631-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (60)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
DCC mediated attractive signaling
Reactome
DSCAM interactions
Reactome
Developmental Biology
Reactome
Netrin mediated repulsion signals
Name
Explore in Pharos
Explore in Source
Axon guidance
DCC mediated attractive signaling
DSCAM interactions
Developmental Biology
Netrin mediated repulsion signals
Gene Ontology Terms (20)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (179)
1 – 10 of 179
OS9
Tbio
Novelty: 0.01490339
p_int: 0.998798563
p_ni: 0.000981741
p_wrong: 0.000219696
Data Source: BioPlex
NEUROG3
Tbio
Family: TF
Novelty: 0.00341077
p_int: 0.997368434
p_ni: 0.002615635
p_wrong: 0.000015931
Score: 0.275
Data Source: BioPlex,STRINGDB
CCL3L1
Tbio
Novelty: 0.01124082
p_int: 0.98767104
p_ni: 0.012322455
p_wrong: 0.000006505
Data Source: BioPlex
FGF17
Tbio
Novelty: 0.01432991
p_int: 0.830135622
p_ni: 0.006706334
p_wrong: 0.163158044
Score: 0.222
Data Source: BioPlex,STRINGDB
DCC
Tbio
Novelty: 0.01273911
Score: 0.998
Data Source: Reactome,STRINGDB
UNC5B
Tbio
Novelty: 0.01474065
Score: 0.998
Data Source: Reactome,STRINGDB
UNC5A
Tbio
Novelty: 0.03749855
Score: 0.995
Data Source: Reactome,STRINGDB
NEO1
Tbio
Novelty: 0.00625858
Score: 0.995
Data Source: Reactome,STRINGDB
UNC5C
Tbio
Novelty: 0.02045906
Score: 0.995
Data Source: Reactome,STRINGDB
DSCAM
Tbio
Novelty: 0.00418718
Score: 0.987
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  653.63

PubMed score by year
PubTator Score  251.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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