Tchem STAMBP STAM-binding protein

Protein Summary

Description

Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95630
• B5M0B6
• D6W5H7
• Q3MJE7

Gene Name

• STAMBP

Ensembl ID

• ENST00000339566
• ENSP00000344742
• ENSG00000124356
• ENST00000394070
• ENSP00000377633
• ENST00000394073
• ENSP00000377636
• ENST00000409707
• ENSP00000386548

Symbol

• AMSH
• AMSH
• MICCAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
disease perturbation	0.9
cell type or tissue	0.84
virus perturbation	0.79
histone modification site profile	0.71

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Stam-binding Protein

Protein / ... / Metalloprotease / Stam-binding Protein

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Stam-binding Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.64   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 277   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.64   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (6)

Explore Active Ligands

1 – 6 of 6

8,8'-Disulfanediylbis(N-(4-morpholinobenzyl)quinoline-3-carboxamide)

STAMBPTchem

pIC50 : 6.52

CHEMBL4104719

STAMBPTchem

pIC50 : 6.7

CHEMBL4095913,CHEMBL4091693

STAMBPTchem

pIC50 : 6.05

8,8'-Disulfanediylbis(N-(4-methoxybenzyl)quinoline-3-carboxamide)

STAMBPTchem

pIC50 : 6.3

CHEMBL4586347

STAMBPTchem

pIC50 : 6.48

8,8'-Disulfanediylbis(N-(4-fluorobenzyl)quinoline-3-carboxamide)

STAMBPTchem

pIC50 : 6.05

Protein-Protein Interactions (171)

Explore Interacting Targets

1 – 10 of 171

• See Interactions on String-DB

GRAP2

Tbio

Novelty:  0.00503901

p_int:  0.999999835

p_ni:  1.61e-7

p_wrong:  4e-9

Score:  0.354

Data Source:  BioPlex,STRINGDB

STAMBPL1

Tbio

Family:  Enzyme

Novelty:  0.08532786

p_int:  0.999999686

p_ni:  3.13e-7

p_wrong:  1e-9

Score:  0.69

Data Source:  BioPlex,STRINGDB

CHMP3

Tbio

Novelty:  0.01958573

p_int:  0.999999193

p_ni:  8.07e-7

Score:  0.921

Data Source:  BioPlex,STRINGDB

CLTCL1

Tbio

Novelty:  0.05667807

p_int:  0.999997933

p_ni:  0.000002067

Score:  0.238

Data Source:  BioPlex,STRINGDB

CDKL3

Tchem

Family:  Kinase

Novelty:  0.15663603

p_int:  0.99999148

p_ni:  0.00000852

Score:  0.516

Data Source:  BioPlex,STRINGDB

PIK3C2A

Tchem

Family:  Kinase

Novelty:  0.0002219

p_int:  0.99991797

p_ni:  0.00008203

Score:  0.659

Data Source:  BioPlex,STRINGDB

BMP2K

Tchem

Family:  Kinase

Novelty:  0.10145601

p_int:  0.999853768

p_ni:  0.000146232

Score:  0.688

Data Source:  BioPlex,STRINGDB

GRB2

Tchem

Novelty:  0.00091605

p_int:  0.999701025

p_ni:  0.000298975

Score:  0.623

Data Source:  BioPlex,STRINGDB

GAK

Tchem

Family:  Kinase

Novelty:  0.00731928

p_int:  0.99942816

p_ni:  0.000571839

p_wrong:  1e-9

Score:  0.381

Data Source:  BioPlex,STRINGDB

CHMP1A

Tbio

Novelty:  0.03969333

p_int:  0.999208936

p_ni:  0.000790885

p_wrong:  1.78e-7

Score:  0.809

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

Reactome (4)

KEGG (1)

PathwayCommons (2)

WikiPathways (1)

Deubiquitination (R-HSA-5688426)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Deubiquitination	278 targets	R-HSA-5688426
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Metalloprotease DUBs	28 targets	R-HSA-5689901
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Deubiquitination	278 targets	R-HSA-5688426
Metabolism of proteins	2050 targets	R-HSA-392499
Metalloprotease DUBs	28 targets	R-HSA-5689901
Post-translational protein modification	1450 targets	R-HSA-597592

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (20)

Functions (5)

Components (8)

Processes (7)

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Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
thiol-dependent ubiquitin-specific protease activity	Inferred from Direct Assay (IDA)	MGI
protein domain specific binding	Inferred from Physical Interaction (IPI)	UniProtKB
Lys63-specific deubiquitinase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metallopeptidase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum metabolite measurement	EFO_0005653	1	3	3		90.5
creatinine measurement	EFO_0004518	1	2	2		59
glomerular filtration rate	EFO_0005208	1	2	2		59
lymphocyte count	EFO_0004587	1	1	1		42.3
mitochondrial DNA measurement	EFO_0006312	1	1	1		28.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum metabolite measurement	EFO_0005653	3		90.5
creatinine measurement	EFO_0004518	2		59
glomerular filtration rate	EFO_0005208	2		59
lymphocyte count	EFO_0004587	1		42.3
mitochondrial DNA measurement	EFO_0006312	1		28.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Disease mutation
Endosome
Hydrolase
Membrane
Metal-binding
Metalloprotease

GWAS Trait Find Similar Targets

No Header	No Header
creatinine measurement
glomerular filtration rate
lymphocyte count
mitochondrial DNA measurement
serum metabolite measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging
nervous system phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	STAM binding protein	VGNC:384	739448
Macaque	STAM binding protein		714562
Mouse	STAM binding protein	MGI:1917777	70527
Rat	Stam binding protein	RGD:619963	171565
Horse	STAM binding protein	VGNC:23652	100049814

Species	Name	OMA	EggNOG	Inparanoid
Chimp	STAM binding protein
Macaque	STAM binding protein
Mouse	STAM binding protein
Rat	Stam binding protein
Horse	STAM binding protein

Publication Statistics

PubMed Score 68.64

PubMed score by year

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PubTator Score 39.28

PubTator score by year

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Related Publications

Text Mined References (56)

GeneRif Annotations (22)

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10

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PMID	Year	Title