Protein Summary
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain ...more
- ENST00000339566
- ENSP00000344742
- ENSG00000124356
- ENST00000394070
- ENSP00000377633
- ENST00000394073
- ENSP00000377636
- ENST00000409707
- ENSP00000386548
- AMSH
- AMSH
- MICCAP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.91 | ||
disease perturbation | 0.9 | ||
cell type or tissue | 0.84 | ||
virus perturbation | 0.79 | ||
histone modification site profile | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 68.64 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 277 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 68.64 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 277 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (6)
Protein-Protein Interactions (171)
GRAP2
Novelty: 0.00503901
p_int: 0.999999835
p_ni: 1.61e-7
p_wrong: 4e-9
Score: 0.354
Data Source: BioPlex,STRINGDB
STAMBPL1
Family: Enzyme
Novelty: 0.08532786
p_int: 0.999999686
p_ni: 3.13e-7
p_wrong: 1e-9
Score: 0.69
Data Source: BioPlex,STRINGDB
CHMP3
Novelty: 0.01958573
p_int: 0.999999193
p_ni: 8.07e-7
Score: 0.921
Data Source: BioPlex,STRINGDB
CLTCL1
Novelty: 0.05667807
p_int: 0.999997933
p_ni: 0.000002067
Score: 0.238
Data Source: BioPlex,STRINGDB
CDKL3
Family: Kinase
Novelty: 0.15663603
p_int: 0.99999148
p_ni: 0.00000852
Score: 0.516
Data Source: BioPlex,STRINGDB
PIK3C2A
Family: Kinase
Novelty: 0.0002219
p_int: 0.99991797
p_ni: 0.00008203
Score: 0.659
Data Source: BioPlex,STRINGDB
BMP2K
Family: Kinase
Novelty: 0.10145601
p_int: 0.999853768
p_ni: 0.000146232
Score: 0.688
Data Source: BioPlex,STRINGDB
GRB2
Novelty: 0.00091605
p_int: 0.999701025
p_ni: 0.000298975
Score: 0.623
Data Source: BioPlex,STRINGDB
GAK
Family: Kinase
Novelty: 0.00731928
p_int: 0.99942816
p_ni: 0.000571839
p_wrong: 1e-9
Score: 0.381
Data Source: BioPlex,STRINGDB
CHMP1A
Novelty: 0.03969333
p_int: 0.999208936
p_ni: 0.000790885
p_wrong: 1.78e-7
Score: 0.809
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (4)
KEGG (1)
PathwayCommons (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Deubiquitination | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Metalloprotease DUBs | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Deubiquitination | ||||
Metabolism of proteins | ||||
Metalloprotease DUBs | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (5)
Components (8)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
serum metabolite measurement | 1 | 3 | 3 | 90.5 | |||||
creatinine measurement | 1 | 2 | 2 | 59 | |||||
glomerular filtration rate | 1 | 2 | 2 | 59 | |||||
lymphocyte count | 1 | 1 | 1 | 42.3 | |||||
mitochondrial DNA measurement | 1 | 1 | 1 | 28.8 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
serum metabolite measurement | 3 | 90.5 | |||||
creatinine measurement | 2 | 59 | |||||
glomerular filtration rate | 2 | 59 | |||||
lymphocyte count | 1 | 42.3 | |||||
mitochondrial DNA measurement | 1 | 28.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | STAM binding protein | VGNC:384 | 739448 | |||||
Macaque | STAM binding protein | 714562 | ||||||
Mouse | MGI:1917777 | 70527 | ||||||
Rat | RGD:619963 | 171565 | ||||||
Horse | STAM binding protein | VGNC:23652 | 100049814 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | STAM binding protein | |||||
Macaque | STAM binding protein | |||||
Mouse | ||||||
Rat | ||||||
Horse | STAM binding protein | |||||
Publication Statistics
PubMed Score 68.64
PubMed score by year
PubTator Score 39.28
PubTator score by year
Related Publications
Text Mined References (56)
GeneRif Annotations (22)
Items per page:
0 of 0
PMID | Year | Title |
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