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Tbio
STAMBP
STAM-binding protein

Protein Summary
Description
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339566
  • ENSP00000344742
  • ENSG00000124356
  • ENST00000394070
  • ENSP00000377633
  • ENST00000394073
  • ENSP00000377636
  • ENST00000409707
  • ENSP00000386548

Symbol
  • AMSH
  • AMSH
  • MICCAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
disease perturbation
0.9
cell type or tissue
0.84
virus perturbation
0.79
histone modification site profile
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
 GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.97   (req: < 5)
View Publications
Gene RIFs: 22   (req: <= 3)
View Gene RIFs
Antibodies: 277   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.97   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
EFO_0005653
1
2
2
86.1
Items per page:
1 – 1 of 1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
EFO_0005653
2
86.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
STAM binding protein
VGNC:384
739448
Macaque
STAM binding protein
714562
Mouse
STAM binding protein
MGI:1917777
70527
Rat
Stam binding protein
RGD:619963
171565
Horse
STAM binding protein
VGNC:23652
100049814
Species
Name
OMA
EggNOG
Inparanoid
Chimp
STAM binding protein
Macaque
STAM binding protein
Mouse
STAM binding protein
Rat
Stam binding protein
Horse
STAM binding protein
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
278 targets
R-HSA-5688426
Reactome
Metabolism of proteins
2050 targets
R-HSA-392499
Reactome
Metalloprotease DUBs
28 targets
R-HSA-5689901
Reactome
Post-translational protein modification
1450 targets
R-HSA-597592
Name
Explore in Pharos
Explore in Source
Deubiquitination
278 targets
R-HSA-5688426
Metabolism of proteins
2050 targets
R-HSA-392499
Metalloprotease DUBs
28 targets
R-HSA-5689901
Post-translational protein modification
1450 targets
R-HSA-597592
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
thiol-dependent ubiquitin-specific protease activity
Inferred from Direct Assay (IDA)
MGI
protein domain specific binding
Inferred from Physical Interaction (IPI)
UniProtKB
Lys63-specific deubiquitinase activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
metal ion binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
metallopeptidase activity
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (171)
1 – 10 of 171
GRAP2
Tbio
Novelty: 0.00503901
p_int: 0.999999835
p_ni: 1.61e-7
p_wrong: 4e-9
Score: 0.354
Data Source: BioPlex,STRINGDB
STAMBPL1
Tbio
Family: Enzyme
Novelty: 0.08532786
p_int: 0.999999686
p_ni: 3.13e-7
p_wrong: 1e-9
Score: 0.69
Data Source: BioPlex,STRINGDB
CHMP3
Tbio
Novelty: 0.01958573
p_int: 0.999999193
p_ni: 8.07e-7
Score: 0.921
Data Source: BioPlex,STRINGDB
CLTCL1
Tbio
Novelty: 0.05667807
p_int: 0.999997933
p_ni: 0.000002067
Score: 0.238
Data Source: BioPlex,STRINGDB
CDKL3
Tchem
Family: Kinase
Novelty: 0.15663603
p_int: 0.99999148
p_ni: 0.00000852
Score: 0.516
Data Source: BioPlex,STRINGDB
PIK3C2A
Tchem
Family: Kinase
Novelty: 0.0002219
p_int: 0.99991797
p_ni: 0.00008203
Score: 0.659
Data Source: BioPlex,STRINGDB
BMP2K
Tchem
Family: Kinase
Novelty: 0.10145601
p_int: 0.999853768
p_ni: 0.000146232
Score: 0.688
Data Source: BioPlex,STRINGDB
GRB2
Tchem
Novelty: 0.00091605
p_int: 0.999701025
p_ni: 0.000298975
Score: 0.623
Data Source: BioPlex,STRINGDB
GAK
Tchem
Family: Kinase
Novelty: 0.00731928
p_int: 0.99942816
p_ni: 0.000571839
p_wrong: 1e-9
Score: 0.381
Data Source: BioPlex,STRINGDB
CHMP1A
Tbio
Novelty: 0.03969333
p_int: 0.999208936
p_ni: 0.000790885
p_wrong: 1.78e-7
Score: 0.809
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  65.97

PubMed score by year
PubTator Score  39.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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