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Tbio
YEATS4
YEATS domain-containing protein 4

Protein Summary
Description
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247843
  • ENSP00000247843
  • ENSG00000127337

Symbol
  • GAS41
  • YAF9
  • GAS41
  • NUBI-1
  • 4930573H17Rik
  • B230215M10Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
histone modification site profile
0.85
cellular component
0.74
interacting protein
0.72
biological process
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.11   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 367   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.11   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 367   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (206)
SNX16
Tbio
Novelty:  0.13364491
p_int:  0.999999454
p_ni:  5.42e-7
p_wrong:  3e-9
Score:  0.224
Data Source:  BioPlex,STRINGDB
KAT5
Tchem
Family:  Epigenetic
Novelty:  0.00368348
p_int:  0.999998513
p_ni:  0.000001487
Score:  0.991
Data Source:  BioPlex,STRINGDB
WEE1
Tchem
Family:  Kinase
Novelty:  0.00162432
p_int:  0.999997788
p_ni:  0.000002032
p_wrong:  1.8e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
ACTR6
Tbio
Novelty:  0.11005766
p_int:  0.999996365
p_ni:  0.000003635
Score:  0.943
Data Source:  BioPlex,STRINGDB
VPS72
Tbio
Novelty:  0.00561093
p_int:  0.999995821
p_ni:  0.000004179
Score:  0.994
Data Source:  BioPlex,STRINGDB
SRCAP
Tbio
Family:  Enzyme
Novelty:  0.02446238
p_int:  0.999993828
p_ni:  0.000006172
Score:  0.922
Data Source:  BioPlex,STRINGDB
MEAF6
Tbio
Novelty:  0.0914094
p_int:  0.99999257
p_ni:  0.00000743
Score:  0.994
Data Source:  BioPlex,STRINGDB
EPC1
Tbio
Novelty:  0.03216371
p_int:  0.999989612
p_ni:  0.000010387
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
MBTD1
Tbio
Family:  Epigenetic
Novelty:  0.11651052
p_int:  0.999979832
p_ni:  0.000020168
Score:  0.849
Data Source:  BioPlex,STRINGDB
ING3
Tbio
Family:  Epigenetic
Novelty:  0.01696145
p_int:  0.999973038
p_ni:  0.000026962
Score:  0.99
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Activation of the TFAP2 (AP-2) family of transcription factors (R-HSA-8866907)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the TFAP2 (AP-2) family of transcription factors
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Activation of the TFAP2 (AP-2) family of transcription factors
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
1
2
88
monocyte percentage of leukocytes
2
1
2
87.7
Oral ulcer
1
1
0
1.1
80.6
granulocyte percentage of myeloid white cells
1
1
1
80.4
BMI-adjusted hip circumference
3
3
7
79.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
88
monocyte percentage of leukocytes
2
87.7
Oral ulcer
0
1.1
80.6
granulocyte percentage of myeloid white cells
1
80.4
BMI-adjusted hip circumference
7
79.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
YEATS domain containing 4
VGNC:5654
452069
Mouse
MGI:1927224
64050
Rat
RGD:1305741
299810
Dog
YEATS domain containing 4
VGNC:48483
474443
Horse
YEATS domain containing 4
VGNC:25097
100059724
Species
Name
OMA
EggNOG
Inparanoid
Chimp
YEATS domain containing 4
Mouse
Rat
Dog
YEATS domain containing 4
Horse
YEATS domain containing 4
Publication Statistics
PubMed Score 48.11
PubMed score by year
PubTator Score 19.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title