Tbio PCNT Pericentrin

Protein Summary

Description

Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• O95613
• O43152
• Q7Z7C9

Gene Name

• PCNT

Ensembl ID

• ENST00000359568
• ENSP00000352572
• ENSG00000160299

Symbol

• KIAA0402
• PCNT2
• KEN
• PCN
• MOPD2
• PCNT2
• PCNTB
• PCTN2
• SCKL4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
histone modification site profile	0.85
cellular component	0.84
transcription factor binding site profile	0.75
interacting protein	0.74

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.57   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.57   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2	2	2		69.1
viral load	EFO_0010125	1	1	1		59.9
HIV-1 infection	EFO_0000180	1	1	1		59.9
type II diabetes mellitus	EFO_0001360	1	1	1		52.3
breast carcinoma	EFO_0000305	1	1	0	1.1	51.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2		69.1
viral load	EFO_0010125	1		59.9
HIV-1 infection	EFO_0000180	1		59.9
type II diabetes mellitus	EFO_0001360	1		52.3
breast carcinoma	EFO_0000305	0	1.1	51.6

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Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	pericentrin	VGNC:1136	474062
Macaque	pericentrin		106997206
Mouse	pericentrin (kendrin)	MGI:102722	18541
Rat	pericentrin	RGD:1595865	309692
Dog	disco interacting protein 2 homolog A		491614

Species	Name	OMA	EggNOG	Inparanoid
Chimp	pericentrin
Macaque	pericentrin
Mouse	pericentrin (kendrin)
Rat	pericentrin
Dog	disco interacting protein 2 homolog A

Protein Structure (0 Structures, 11 AlphaFold Models)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-O95613-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)

Reactome (16)

WikiPathways (3)

AURKA Activation by TPX2 (R-HSA-8854518)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	AURKA Activation by TPX2	72 targets	R-HSA-8854518
Reactome	Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Centrosome maturation	81 targets	R-HSA-380287

Name	Explore in Pharos	Explore in Source
AURKA Activation by TPX2	72 targets	R-HSA-8854518
Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Centrosome maturation	81 targets	R-HSA-380287

Gene Ontology Terms (17)

Functions (2)

Components (7)

Processes (8)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
calmodulin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protein-containing complex scaffold activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (274)

Explore Interacting Targets

1 – 10 of 274

• See Interactions on String-DB

LPXN

Tbio

Novelty: 0.00796678

p_int: 0.999998421

p_ni: 0.000001579

Data Source: BioPlex

BRK1

Tbio

Novelty: 0.02289534

p_int: 0.999993355

p_ni: 0.000006645

Data Source: BioPlex

IKBIP

Tbio

Family: Enzyme

Novelty: 0.18707639

p_int: 0.999992105

p_ni: 0.000007895

Data Source: BioPlex

FAM81B

Tdark

Novelty: 2.38747104

p_int: 0.999975195

p_ni: 0.000024805

Score: 0.206

Data Source: BioPlex,STRINGDB

CTAG2

Tbio

Novelty: 0.02983879

p_int: 0.999959888

p_ni: 0.000040112

Score: 0.435

Data Source: BioPlex,STRINGDB

MZT1

Tdark

Novelty: 0.06713659

p_int: 0.999939463

p_ni: 0.000060537

Score: 0.948

Data Source: BioPlex,STRINGDB

FGL2

Tbio

Novelty: 0.01108434

p_int: 0.999854533

p_ni: 0.000145467

Score: 0.187

Data Source: BioPlex,STRINGDB

BIRC7

Tchem

Novelty: 0.00420245

p_int: 0.999796075

p_ni: 0.000203925

Score: 0.195

Data Source: BioPlex,STRINGDB

MIS18A

Tbio

Novelty: 0.08143008

p_int: 0.999646522

p_ni: 0.000353478

Data Source: BioPlex

C1orf87

Tbio

Novelty: 0.03162594

p_int: 0.999558571

p_ni: 0.000441429

Score: 0.186

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  256.57

PubMed score by year

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PubTator Score  410.55

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Find similar targets by:

UniProt Keyword Find Similar Targets

Alternative splicing
Calmodulin-binding
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Dwarfism
Microtubule
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

breast carcinoma
heel bone mineral density
HIV-1 infection
type II diabetes mellitus
viral load

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
limbs/digits/tail phenotype
mortality/aging