Protein Summary
Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplas ...more
- ENST00000359568
- ENSP00000352572
- ENSG00000160299
- KIAA0402
- PCNT2
- KEN
- PCN
- MOPD2
- PCNT2
- PCNTB
- PCTN2
- SCKL4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.86 | ||
histone modification site profile | 0.85 | ||
cellular component | 0.84 | ||
transcription factor binding site profile | 0.75 | ||
interacting protein | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 266.4 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 167 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 266.4 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 167 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (274)
IKBIP
Family: Enzyme
Novelty: 0.18707639
p_int: 0.999992105
p_ni: 0.000007895
Data Source: BioPlex
FAM81B
Novelty: 2.38747104
p_int: 0.999975195
p_ni: 0.000024805
Score: 0.206
Data Source: BioPlex,STRINGDB
CTAG2
Novelty: 0.02983879
p_int: 0.999959888
p_ni: 0.000040112
Score: 0.435
Data Source: BioPlex,STRINGDB
MZT1
Novelty: 0.06713659
p_int: 0.999939463
p_ni: 0.000060537
Score: 0.948
Data Source: BioPlex,STRINGDB
FGL2
Novelty: 0.01108434
p_int: 0.999854533
p_ni: 0.000145467
Score: 0.187
Data Source: BioPlex,STRINGDB
BIRC7
Novelty: 0.00420245
p_int: 0.999796075
p_ni: 0.000203925
Score: 0.195
Data Source: BioPlex,STRINGDB
C1orf87
Novelty: 0.03162594
p_int: 0.999558571
p_ni: 0.000441429
Score: 0.186
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (19)
Reactome (16)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | AURKA Activation by TPX2 | ||||
Reactome | Anchoring of the basal body to the plasma membrane | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Centrosome maturation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
AURKA Activation by TPX2 | ||||
Anchoring of the basal body to the plasma membrane | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Centrosome maturation | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (2)
Components (7)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 3 | 3 | 88.7 | |||||
S100 calcium-binding protein B measurement | 1 | 1 | 1 | 88.4 | |||||
myeloid white cell count | 1 | 1 | 1 | 72.9 | |||||
neutrophil count | 2 | 2 | 2 | 68.4 | |||||
viral load | 1 | 1 | 1 | 67.1 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 88.7 | |||||
S100 calcium-binding protein B measurement | 1 | 88.4 | |||||
myeloid white cell count | 1 | 72.9 | |||||
neutrophil count | 2 | 68.4 | |||||
viral load | 1 | 67.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | pericentrin | VGNC:1136 | 474062 | |||||
Macaque | pericentrin | 106997206 | ||||||
Mouse | MGI:102722 | 18541 | ||||||
Rat | RGD:1595865 | 309692 | ||||||
Dog | disco interacting protein 2 homolog A | 491614 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | pericentrin | |||||
Macaque | pericentrin | |||||
Mouse | ||||||
Rat | ||||||
Dog | disco interacting protein 2 homolog A | |||||
Publication Statistics
PubMed Score 266.40
PubMed score by year
PubTator Score 410.55
PubTator score by year
Related Publications
Text Mined References (65)
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Year | Title |
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