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Tbio
KLF8
Krueppel-like factor 8

Protein Summary
Description
Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374928
  • ENSP00000364063
  • ENSG00000102349
  • ENST00000468660
  • ENSP00000417303
  • ENST00000640927
  • ENSP00000492126

Symbol
  • BKLF3
  • ZNF741
  • BKLF3
  • ZNF741
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.57
cell type or tissue
0.54
microRNA
0.53
biological term
0.47
gene perturbation
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.83   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.83   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
2
2
64.2
Alopecia
1
1
1
17.8
1
1
0
1.7
17.1
prostate specific antigen measurement
1
1
1
1.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
64.2
Alopecia
1
17.8
0
1.7
17.1
prostate specific antigen measurement
1
1.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Kruppel like factor 8
465661
Macaque
Kruppel like factor 8
704591
Mouse
MGI:2442430
245671
Rat
RGD:1565831
302582
Dog
Kruppel like factor 8
VGNC:42438
612672
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Kruppel like factor 8
Macaque
Kruppel like factor 8
Mouse
Rat
Dog
Kruppel like factor 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95600-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (49)
1 – 10 of 49
CTBP2
Tchem
Novelty:  0.00538964
Score:  0.82
Data Source:  STRINGDB
TCF7L1
Tbio
Family:  TF
Novelty:  0.03807371
Score:  0.675
Data Source:  STRINGDB
CDH1
Tbio
Novelty:  0.00010629
Score:  0.674
Data Source:  STRINGDB
SART1
Tbio
Novelty:  0.00835627
Score:  0.64
Data Source:  STRINGDB
PQLC3
Tdark
Novelty:  2.0324719
Score:  0.628
Data Source:  STRINGDB
FOXC2
Tbio
Family:  TF
Novelty:  0.00438844
Score:  0.571
Data Source:  STRINGDB
CTBP1
Tbio
Novelty:  0.00243818
Score:  0.558
Data Source:  STRINGDB
KDM5B
Tchem
Family:  TF; Epigenetic
Novelty:  0.00610414
Score:  0.546
Data Source:  STRINGDB
CD151
Tbio
Novelty:  0.00295527
Score:  0.542
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.534
Data Source:  STRINGDB
Publication Statistics
PubMed Score  72.83

PubMed score by year
PubTator Score  39.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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