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Tbio
ACSL3
Long-chain-fatty-acid--CoA ligase 3

Protein Classes
Protein Summary
Description
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins). The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357430
  • ENSP00000350012
  • ENSG00000123983
  • ENST00000392066
  • ENSP00000375918

Symbol
  • ACS3
  • FACL3
  • LACS3
  • ACS3
  • FACL3
  • LACS3
  • LACS 3
  • PRO2194
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
virus perturbation
0.9
biological process
0.86
transcription factor binding site profile
0.83
microRNA
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.3   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.3   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase long chain family member 3
VGNC:54
459974
Macaque
acyl-CoA synthetase long chain family member 3
706050
Mouse
MGI:1921455
74205
Rat
RGD:70552
114024
Dog
acyl-CoA synthetase long chain family member 3
VGNC:37533
478927
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase long chain family member 3
Macaque
acyl-CoA synthetase long chain family member 3
Mouse
Rat
Dog
acyl-CoA synthetase long chain family member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95573-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (29)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Free fatty acids regulate insulin secretion
Reactome
Integration of energy metabolism
Reactome
Intracellular metabolism of fatty acids regulates insulin secretion
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Free fatty acids regulate insulin secretion
Integration of energy metabolism
Intracellular metabolism of fatty acids regulates insulin secretion
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (122)
1 – 10 of 122
GNAT2
Tbio
Novelty: 0.01683655
p_int: 0.772980184
p_ni: 0.227019816
Score: 0.544
Data Source: BioPlex,STRINGDB
ACOX1
Tbio
Family: Enzyme
Novelty: 0.00473427
Score: 0.962
Data Source: STRINGDB
ACADL
Tbio
Family: Enzyme
Novelty: 0.0298212
Score: 0.956
Data Source: STRINGDB
FASN
Tchem
Family: Enzyme
Novelty: 0.00142172
Score: 0.952
Data Source: STRINGDB
ACOX2
Tbio
Family: Enzyme
Novelty: 0.02942359
Score: 0.95
Data Source: STRINGDB
ELOVL6
Tchem
Novelty: 0.00817818
Score: 0.937
Data Source: STRINGDB
FADS2
Tbio
Family: Enzyme
Novelty: 0.00180901
Score: 0.933
Data Source: STRINGDB
ELOVL1
Tbio
Novelty: 0.03178348
Score: 0.919
Data Source: STRINGDB
MGLL
Tchem
Family: Enzyme
Novelty: 0.00196912
Score: 0.86
Data Source: STRINGDB
LPL
Tchem
Family: Enzyme
Novelty: 0.00057058
Score: 0.838
Data Source: STRINGDB
Publication Statistics
PubMed Score  54.30

PubMed score by year
PubTator Score  32.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer