Tbio MPC2 Mitochondrial pyruvate carrier 2

Protein Summary

Description

Mediates the uptake of pyruvate into mitochondria.

Uniprot Accession IDs

• O95563
• A8K261
• Q3SXR6
• Q6FIF3

Gene Name

• MPC2

Ensembl ID

• ENST00000271373
• ENSP00000271373
• ENSG00000143158
• ENST00000367846
• ENSP00000356820

Symbol

• BRP44
• BRP44
• SLC54A2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
transcription factor perturbation	0.97
disease perturbation	0.83
transcription factor binding site profile	0.83
cell type or tissue	0.62

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc54 Mitochondrial Pyruvate Carriers / Mitochondrial Pyruvate Carrier 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.14   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 192   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.14   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0