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Tbio
MPC2
Mitochondrial pyruvate carrier 2

Protein Summary
Description
Mediates the uptake of pyruvate into mitochondria.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271373
  • ENSP00000271373
  • ENSG00000143158
  • ENST00000367846
  • ENSP00000356820

Symbol
  • BRP44
  • BRP44
  • SLC54A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.97
disease perturbation
0.83
transcription factor binding site profile
0.83
cell type or tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.6   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.6   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.999668316
p_ni:  0.000331684
Data Source:  BioPlex
MPC1
Tbio
Novelty:  0.01315849
p_int:  0.998104717
p_ni:  0.001895281
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
FLOT2
Tbio
Novelty:  0.00727325
p_int:  0.975256648
p_ni:  0.02474268
p_wrong:  6.71e-7
Score:  0.513
Data Source:  BioPlex,STRINGDB
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
p_int:  0.880094705
p_ni:  0.117643743
p_wrong:  0.002261552
Score:  0.19
Data Source:  BioPlex,STRINGDB
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
p_int:  0.857180254
p_ni:  0.14263748
p_wrong:  0.000182266
Data Source:  BioPlex
OGFOD3
Tdark
Family:  Enzyme
Novelty:  0.86903294
p_int:  0.852960343
p_ni:  0.131702882
p_wrong:  0.015336775
Score:  0.199
Data Source:  BioPlex,STRINGDB
TMEM171
Tdark
Novelty:  2.00247773
p_int:  0.833536582
p_ni:  0.15507945
p_wrong:  0.011383967
Data Source:  BioPlex
TIMM17B
Tdark
Family:  Enzyme
Novelty:  0.03556998
Score:  0.798
Data Source:  STRINGDB
TEX44
Tdark
Novelty:  1.50660793
Score:  0.794
Data Source:  STRINGDB
MINOS1
Tdark
Novelty:  0.40437095
Score:  0.772
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (51)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial pyruvate carrier 2
VGNC:1327
748336
Macaque
mitochondrial pyruvate carrier 2
698807
Mouse
MGI:1917706
70456
Rat
RGD:1563422
100359982
Dog
mitochondrial pyruvate carrier 2
VGNC:43330
480086
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial pyruvate carrier 2
Macaque
mitochondrial pyruvate carrier 2
Mouse
Rat
Dog
mitochondrial pyruvate carrier 2
Publication Statistics
PubMed Score 39.60
PubMed score by year
PubTator Score 16.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title