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Tchem
TDP2
Tyrosyl-DNA phosphodiesterase 2

Protein Summary
Description
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378198
  • ENSP00000367440
  • ENSG00000111802

Symbol
  • EAP2
  • TTRAP
  • EAP2
  • AD022
  • EAPII
  • TTRAP
  • hTDP2
  • dJ30M3.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
molecular function
0.9
histone modification site profile
0.87
virus perturbation
0.79
transcription factor binding site profile
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.93   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.93   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 46
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
38.2
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (41)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Nonhomologous End-Joining (NHEJ)
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
Nonhomologous End-Joining (NHEJ)
Gene Ontology Terms (17)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (120)
1 – 10 of 120
PLA2G10
Tchem
Family: Enzyme
Novelty: 0.00289317
p_int: 0.999957587
p_ni: 0.000042412
p_wrong: 1e-9
Data Source: BioPlex
C10orf82
Tdark
Novelty: 7.20110868
p_int: 0.999763625
p_ni: 0.000236371
p_wrong: 4e-9
Data Source: BioPlex
TCEAL1
Tbio
Novelty: 0.02210924
p_int: 0.998452818
p_ni: 0.001435063
p_wrong: 0.000112119
Score: 0.181
Data Source: BioPlex,STRINGDB
RNF7
Tbio
Novelty: 0.02532658
p_int: 0.998342701
p_ni: 0.001656794
p_wrong: 5.05e-7
Data Source: BioPlex
RNF181
Tbio
Family: Enzyme
Novelty: 0.27482636
p_int: 0.994181352
p_ni: 0.00510371
p_wrong: 0.000714938
Data Source: BioPlex
AZIN1
Tbio
Family: Enzyme
Novelty: 0.03017595
p_int: 0.990138778
p_ni: 0.009834175
p_wrong: 0.000027046
Score: 0.316
Data Source: BioPlex,STRINGDB
LYPD4
Tbio
Novelty: 0.00381728
p_int: 0.966971574
p_ni: 0.003975574
p_wrong: 0.029052853
Data Source: BioPlex
GORASP1
Tbio
Novelty: 0.02332405
p_int: 0.946563738
p_ni: 0.053414337
p_wrong: 0.000021925
Data Source: BioPlex
RSBN1
Tbio
Novelty: 0.1955858
p_int: 0.920501661
p_ni: 0.079440002
p_wrong: 0.000058337
Data Source: BioPlex
EXOSC3
Tbio
Novelty: 0.03072164
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  103.93

PubMed score by year
PubTator Score  59.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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