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Tbio
NADK
NAD kinase

Protein Summary
Description
NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341426
  • ENSP00000341679
  • ENSG00000008130
  • ENST00000341991
  • ENSP00000344340
  • ENST00000378625
  • ENSP00000367890

Symbol
  • dJ283E3.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
molecular function
0.93
transcription factor binding site profile
0.89
kinase perturbation
0.84
transcription factor
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.22   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.22   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
RBM42
Tdark
Novelty:  0.37655036
p_int:  0.905739651
p_ni:  0.094260349
Score:  0.243
Data Source:  BioPlex,STRINGDB
NADK2
Tbio
Family:  Kinase
Novelty:  0.12395524
Score:  0.979
Data Source:  STRINGDB
NMNAT3
Tbio
Family:  Enzyme
Novelty:  0.03261313
Score:  0.974
Data Source:  STRINGDB
NMNAT1
Tbio
Family:  Enzyme
Novelty:  0.01110899
Score:  0.974
Data Source:  STRINGDB
NMNAT2
Tbio
Family:  Enzyme
Novelty:  0.01709189
Score:  0.973
Data Source:  STRINGDB
NADSYN1
Tbio
Family:  Enzyme
Novelty:  0.0445844
Score:  0.972
Data Source:  STRINGDB
NNT
Tbio
Family:  Enzyme
Novelty:  0.00269343
Score:  0.952
Data Source:  STRINGDB
CD38
Tclin
Family:  Enzyme
Novelty:  0.00034991
Score:  0.932
Data Source:  STRINGDB
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
Score:  0.929
Data Source:  STRINGDB
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
Score:  0.924
Data Source:  STRINGDB
Pathways (9)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinate metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
3
4
86.8
body height
1
1
1
61.4
reticulocyte count
1
1
1
38.8
reticulocyte measurement
1
1
1
35
electrocardiography
1
1
3
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
86.8
body height
1
61.4
reticulocyte count
1
38.8
reticulocyte measurement
1
35
electrocardiography
3
28.1
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
NAD kinase
708852
Mouse
MGI:2183149
192185
Rat
RGD:1642420
100125370
Dog
NAD kinase
VGNC:43605
489589
Horse
NAD kinase
VGNC:20543
100061432
Species
Name
OMA
EggNOG
Inparanoid
Macaque
NAD kinase
Mouse
Rat
Dog
NAD kinase
Horse
NAD kinase
Publication Statistics
PubMed Score 36.22
PubMed score by year
PubTator Score 55.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title