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Tchem
CBX6
Chromobox protein homolog 6

Protein Summary
Description
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407418
  • ENSP00000384490
  • ENSG00000183741
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
disease perturbation
0.83
transcription factor
0.75
protein domain
0.73
phenotype
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.53   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.53   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1.5
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3512628
494448
Rat
RGD:1307314
315136
Cow
chromobox 6
VGNC:26819
513830
Opossum
chromobox 6 [Source:HGNC Symbol;Acc:HGNC:1556]
Xenopus
chromobox 6
XB-GENE-951161
549371
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
chromobox 6
Opossum
chromobox 6 [Source:HGNC Symbol;Acc:HGNC:1556]
Xenopus
chromobox 6
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95503-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (142)
1 – 10 of 142
PHC1
Tbio
Novelty: 0.01530622
p_int: 0.999868753
p_ni: 0.000131247
Score: 0.978
Data Source: BioPlex,STRINGDB
SFTPC
Tbio
Novelty: 0.00154396
p_int: 0.999817411
p_ni: 0.000182589
Score: 0.169
Data Source: BioPlex,STRINGDB
PCGF2
Tbio
Novelty: 0.02148755
p_int: 0.99803303
p_ni: 0.00196697
Score: 0.977
Data Source: BioPlex,STRINGDB
PCDH20
Tbio
Novelty: 0.07862843
p_int: 0.996994044
p_ni: 0.003005949
p_wrong: 7e-9
Data Source: BioPlex
PCDHGA5
Tdark
Novelty: 2.13631603
p_int: 0.995297285
p_ni: 0.004702523
p_wrong: 1.92e-7
Data Source: BioPlex
PCDHB16
Tdark
Novelty: 0.67206411
p_int: 0.991358784
p_ni: 0.008641216
Data Source: BioPlex
PCDHGB4
Tdark
Novelty: 0.25018904
p_int: 0.972018365
p_ni: 0.027981631
p_wrong: 4e-9
Data Source: BioPlex
PCDHB11
Tdark
Novelty: 0.80480462
p_int: 0.968734037
p_ni: 0.031265963
Data Source: BioPlex
PCDHGA6
Tdark
Novelty: 1.60910393
p_int: 0.964980219
p_ni: 0.034914722
p_wrong: 0.00010506
Data Source: BioPlex
PCDHB3
Tdark
Novelty: 0.51391546
p_int: 0.947590745
p_ni: 0.052408595
p_wrong: 6.61e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  8.53

PubMed score by year
PubTator Score  3.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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