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Tbio
VNN2
Vascular non-inflammatory molecule 2

Protein Classes
Protein Summary
Description
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil. This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326499
  • ENSP00000322276
  • ENSG00000112303
  • ENST00000525270
  • ENSP00000436822
  • ENST00000525289
  • ENSP00000436935
  • ENST00000525674
  • ENSP00000436863
  • ENST00000532053
  • ENSP00000434077

Symbol
  • FOAP-4
  • GPI-80
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.58
tissue
0.58
tissue sample
0.52
cell line
0.47
PubMedID
0.46


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.77   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.77   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vanin 2
VGNC:3787
463007
Macaque
vanin 2
708637
Horse
vanin 2
VGNC:51097
100067672
Cow
vanin 2
VGNC:36808
534929
Pig
vanin 2
100153984
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vanin 2
Macaque
vanin 2
Horse
vanin 2
Cow
vanin 2
Pig
vanin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95498-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of proteins
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of proteins
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Post-translational modification: synthesis of GPI-anchored proteins
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (147)
1 – 10 of 147
ACADVL
Tbio
Family: Enzyme
Novelty: 0.00383705
p_int: 0.999991208
p_ni: 0.000008792
Score: 0.177
Data Source: BioPlex,STRINGDB
FKBP14
Tbio
Family: Enzyme
Novelty: 0.02742616
p_int: 0.999989285
p_ni: 0.000010527
p_wrong: 1.87e-7
Data Source: BioPlex
COX18
Tbio
Novelty: 0.06288021
p_int: 0.999947239
p_ni: 0.000001814
p_wrong: 0.000050947
Score: 0.222
Data Source: BioPlex,STRINGDB
FZD3
Tbio
Family: GPCR
Novelty: 0.00964507
p_int: 0.999883026
p_ni: 0.000116955
p_wrong: 1.9e-8
Data Source: BioPlex
S1PR5
Tclin
Family: GPCR
Novelty: 0.01032055
p_int: 0.999520613
p_ni: 0.000094454
p_wrong: 0.000384933
Score: 0.175
Data Source: BioPlex,STRINGDB
CLDND1
Tbio
Novelty: 0.06681793
p_int: 0.998787207
p_ni: 0.00076091
p_wrong: 0.000451883
Data Source: BioPlex
KLK7
Tchem
Family: Enzyme
Novelty: 0.00757766
p_int: 0.998348963
p_ni: 0.001639402
p_wrong: 0.000011635
Score: 0.168
Data Source: BioPlex,STRINGDB
ATP2A1
Tchem
Family: Transporter
Novelty: 0.00355092
p_int: 0.997378661
p_ni: 0.002621339
Score: 0.166
Data Source: BioPlex,STRINGDB
FZD6
Tbio
Family: GPCR
Novelty: 0.01425136
p_int: 0.996916929
p_ni: 0.000136585
p_wrong: 0.002946486
Data Source: BioPlex
FZD7
Tbio
Family: GPCR
Novelty: 0.00916448
p_int: 0.995173347
p_ni: 0.000267296
p_wrong: 0.004559357
Data Source: BioPlex
Publication Statistics
PubMed Score  46.77

PubMed score by year
PubTator Score  23.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer