Tbio VNN2 Vascular non-inflammatory molecule 2

Protein Summary

Description

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil. This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• O95498
• A0AUZ3
• A6NDY1
• A8K4E3
• A8K7W0
• B2DFZ0
• B2DFZ1
• B2DFZ2
• B2DFZ3
• F6XL73
• Q2XUN1
• Q9UJF3
• Q9UMW2
• Vanin-2

Gene Name

• VNN2

Ensembl ID

• ENST00000326499
• ENSP00000322276
• ENSG00000112303
• ENST00000525270
• ENSP00000436822
• ENST00000525289
• ENSP00000436935
• ENST00000525674
• ENSP00000436863
• ENST00000532053
• ENSP00000434077

Symbol

• FOAP-4
• GPI-80

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.58
tissue	0.58
tissue sample	0.52
cell line	0.47
PubMedID	0.46

Protein Classes

PANTHER Classes

Protein / Hydrolase / Vascular Non-inflammatory Molecule 2

DTO Classes

Protein / Enzyme / Hydrolase / Vascular Non-inflammatory Molecule 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.12   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.12   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0