Protein Summary
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSe ...more
- ENST00000367928
- ENSP00000356905
- ENSG00000112299
- HDLCQ8
- Tiff66
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.96 | ||
kinase perturbation | 0.81 | ||
PubMedID | 0.79 | ||
cell type or tissue | 0.78 | ||
biological process | 0.75 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.42 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 214 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.42 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 214 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1)
1 – 1 of 1
Protein-Protein Interactions (148)
1 – 10 of 148
COX18
Novelty: 0.06288021
p_int: 0.999993044
p_ni: 0.000006188
p_wrong: 7.69e-7
Data Source: BioPlex
VNN3
Novelty: 0.11036559
p_int: 0.999905144
p_wrong: 0.000094856
Score: 0.91
Data Source: BioPlex,STRINGDB
PCOLCE2
Family: Enzyme
Novelty: 0.13084379
p_int: 0.994021496
p_ni: 0.0052559
p_wrong: 0.000722604
Data Source: BioPlex
SEMA3C
Novelty: 0.00828813
p_int: 0.993045533
p_ni: 0.006331311
p_wrong: 0.000623156
Data Source: BioPlex
SMAD7
Family: TF
Novelty: 0.00116343
p_int: 0.982927725
p_ni: 2.53e-7
p_wrong: 0.017072022
Data Source: BioPlex
TMEM205
Novelty: 0.41048198
p_int: 0.917458388
p_ni: 0.082538045
p_wrong: 0.000003568
Data Source: BioPlex
DHFR2
Family: Enzyme
Novelty: 0.02374466
p_int: 0.820446626
p_ni: 0.019053673
p_wrong: 0.160499702
Data Source: BioPlex
XRCC1
Novelty: 0.00084203
p_int: 0.788721783
p_ni: 0.027301364
p_wrong: 0.183976853
Data Source: BioPlex
GPLD1
Family: Enzyme
Novelty: 0.00627091
Score: 0.919
Data Source: STRINGDB
C3AR1
Family: GPCR
Novelty: 0.00527301
Score: 0.919
Data Source: STRINGDB
Pathways (11)
Reactome (10)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 10
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Metabolism | ||||
Metabolism of proteins | ||||
Metabolism of vitamins and cofactors | ||||
Gene Ontology Terms (16)
Functions (1)
Components (5)
Processes (10)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sensory perception of smell | 1 | 1 | 1 | 63.1 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sensory perception of smell | 1 | 63.1 | |||||
Find similar targets by:
UniProt Keyword
No Header | No Header | ||
|---|---|---|---|
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | vanin 1 | VGNC:12742 | 746544 | |||||
Macaque | vanin 1 | 708830 | ||||||
Mouse | MGI:108395 | 22361 | ||||||
Rat | RGD:1310075 | 29142 | ||||||
Horse | vanin 1 [Source:HGNC Symbol;Acc:HGNC:12705] | |||||||
Publication Statistics
PubMed Score 83.42
PubMed score by year
PubTator Score 44.36
PubTator score by year