Tchem VNN1 Pantetheinase

Protein Summary

Description

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• O95497
• A8K310
• Q4JFW6
• Q4VAS7
• Q4VAS8
• Q4VAS9
• Q9UF16
• Q9UJF4

Gene Name

• VNN1

Ensembl ID

• ENST00000367928
• ENSP00000356905
• ENSG00000112299

Symbol

• HDLCQ8
• Tiff66

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.96
kinase perturbation	0.81
PubMedID	0.79
cell type or tissue	0.78
biological process	0.75

Protein Classes

PANTHER Classes

Protein / Hydrolase / Pantetheinase

DTO Classes

Protein / Enzyme / Hydrolase / Pantetheinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.42   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 214   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.42   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

example 25 [WO2018228934]

VNN1Tchem Enzyme

pIC50 : 10

Protein-Protein Interactions (148)

Explore Interacting Targets

1 – 10 of 148

• See Interactions on String-DB

COX18

Tbio

Novelty:  0.06288021

p_int:  0.999993044

p_ni:  0.000006188

p_wrong:  7.69e-7

Data Source:  BioPlex

VNN3

Tbio

Novelty:  0.11036559

p_int:  0.999905144

p_wrong:  0.000094856

Score:  0.91

Data Source:  BioPlex,STRINGDB

PCOLCE2

Tbio

Family:  Enzyme

Novelty:  0.13084379

p_int:  0.994021496

p_ni:  0.0052559

p_wrong:  0.000722604

Data Source:  BioPlex

SEMA3C

Tbio

Novelty:  0.00828813

p_int:  0.993045533

p_ni:  0.006331311

p_wrong:  0.000623156

Data Source:  BioPlex

SMAD7

Tbio

Family:  TF

Novelty:  0.00116343

p_int:  0.982927725

p_ni:  2.53e-7

p_wrong:  0.017072022

Data Source:  BioPlex

TMEM205

Tdark

Novelty:  0.41048198

p_int:  0.917458388

p_ni:  0.082538045

p_wrong:  0.000003568

Data Source:  BioPlex

DHFR2

Tbio

Family:  Enzyme

Novelty:  0.02374466

p_int:  0.820446626

p_ni:  0.019053673

p_wrong:  0.160499702

Data Source:  BioPlex

XRCC1

Tbio

Novelty:  0.00084203

p_int:  0.788721783

p_ni:  0.027301364

p_wrong:  0.183976853

Data Source:  BioPlex

GPLD1

Tbio

Family:  Enzyme

Novelty:  0.00627091

Score:  0.919

Data Source:  STRINGDB

C3AR1

Tchem

Family:  GPCR

Novelty:  0.00527301

Score:  0.919

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (11)

Reactome (10)

KEGG (1)

Immune System (R-HSA-168256)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Metabolism of vitamins and cofactors	188 targets	R-HSA-196854

Name	Explore in Pharos	Explore in Source
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Metabolism	2112 targets	R-HSA-1430728
Metabolism of proteins	2050 targets	R-HSA-392499
Metabolism of vitamins and cofactors	188 targets	R-HSA-196854

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (1)

Components (5)

Processes (10)

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GO Term	Evidence	Assigned by
pantetheine hydrolase activity	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sensory perception of smell	GO_0007608	1	1	1		63.1

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sensory perception of smell	GO_0007608	1		63.1

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Cell membrane
Complete proteome
Glycoprotein
GPI-anchor
Hydrolase
Lipoprotein
Membrane
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
sensory perception of smell

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	vanin 1	VGNC:12742	746544
Macaque	vanin 1		708830
Mouse	vanin 1	MGI:108395	22361
Rat	vanin 1	RGD:1310075	29142
Horse	vanin 1 [Source:HGNC Symbol;Acc:HGNC:12705]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	vanin 1
Macaque	vanin 1
Mouse	vanin 1
Rat	vanin 1
Horse	vanin 1 [Source:HGNC Symbol;Acc:HGNC:12705]

Publication Statistics

PubMed Score 83.42

PubMed score by year

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PubTator Score 44.36

PubTator score by year

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Related Publications

Text Mined References (40)

GeneRif Annotations (25)

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PMID	Year	Title