Tchem VNN1 Pantetheinase

Protein Summary

Description

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• O95497
• A8K310
• Q4JFW6
• Q4VAS7
• Q4VAS8
• Q4VAS9
• Q9UF16
• Q9UJF4

Gene Name

• VNN1

Ensembl ID

• ENST00000367928
• ENSP00000356905
• ENSG00000112299

Symbol

• HDLCQ8
• Tiff66

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.96
kinase perturbation	0.81
PubMedID	0.79
cell type or tissue	0.78
biological process	0.75

Protein Classes

PANTHER Classes

Protein / Hydrolase / Pantetheinase

DTO Classes

Protein / Enzyme / Hydrolase / Pantetheinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.37   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 214   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.37   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0