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Tchem
VNN1
Pantetheinase

Protein Summary
Description
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367928
  • ENSP00000356905
  • ENSG00000112299

Symbol
  • HDLCQ8
  • Tiff66
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
kinase perturbation
0.81
PubMedID
0.79
cell type or tissue
0.78
biological process
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.42   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.42   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (148)
1 – 10 of 148
COX18
Tbio
Novelty:  0.06288021
p_int:  0.999993044
p_ni:  0.000006188
p_wrong:  7.69e-7
Data Source:  BioPlex
VNN3
Tbio
Novelty:  0.11036559
p_int:  0.999905144
p_wrong:  0.000094856
Score:  0.91
Data Source:  BioPlex,STRINGDB
PCOLCE2
Tbio
Family:  Enzyme
Novelty:  0.13084379
p_int:  0.994021496
p_ni:  0.0052559
p_wrong:  0.000722604
Data Source:  BioPlex
SEMA3C
Tbio
Novelty:  0.00828813
p_int:  0.993045533
p_ni:  0.006331311
p_wrong:  0.000623156
Data Source:  BioPlex
SMAD7
Tbio
Family:  TF
Novelty:  0.00116343
p_int:  0.982927725
p_ni:  2.53e-7
p_wrong:  0.017072022
Data Source:  BioPlex
TMEM205
Tdark
Novelty:  0.41048198
p_int:  0.917458388
p_ni:  0.082538045
p_wrong:  0.000003568
Data Source:  BioPlex
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.820446626
p_ni:  0.019053673
p_wrong:  0.160499702
Data Source:  BioPlex
XRCC1
Tbio
Novelty:  0.00084203
p_int:  0.788721783
p_ni:  0.027301364
p_wrong:  0.183976853
Data Source:  BioPlex
GPLD1
Tbio
Family:  Enzyme
Novelty:  0.00627091
Score:  0.919
Data Source:  STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
Score:  0.919
Data Source:  STRINGDB
Pathways (11)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of proteins
Reactome
Metabolism of vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism
Metabolism of proteins
Metabolism of vitamins and cofactors
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sensory perception of smell
1
1
1
63.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sensory perception of smell
1
63.1
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vanin 1
VGNC:12742
746544
Macaque
vanin 1
708830
Mouse
MGI:108395
22361
Rat
RGD:1310075
29142
Horse
vanin 1 [Source:HGNC Symbol;Acc:HGNC:12705]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vanin 1
Macaque
vanin 1
Mouse
Rat
Horse
vanin 1 [Source:HGNC Symbol;Acc:HGNC:12705]
Publication Statistics
PubMed Score 83.42
PubMed score by year
PubTator Score 44.36
PubTator score by year