Tbio ADGRL2 Adhesion G protein-coupled receptor L2

Protein Summary

Description

Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• O95490
• A5XEI2
• B1ALT8
• B1ALT9
• B1ALU0
• B1ALU2
• B1ALU4
• B1ALU5
• B1ALU6
• O94882
• Q5VX76
• Q9UKY5
• Q9UKY6

Gene Name

• ADGRL2

Ensembl ID

• ENST00000319517
• ENSP00000322270
• ENSG00000117114
• ENST00000359929
• ENSP00000353006
• ENST00000370713
• ENSP00000359748
• ENST00000370715
• ENSP00000359750
• ENST00000370717
• ENSP00000359752
• ENST00000370723
• ENSP00000359758
• ENST00000370725
• ENSP00000359760
• ENST00000370728
• ENSP00000359763
• ENST00000370730
• ENSP00000359765

Symbol

• KIAA0786
• LEC1
• LPHH1
• LPHN2
• CL2
• LEC1
• CIRL2
• LPHH1
• LPHN2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
trait	0.93
disease perturbation	0.83
PubMedID	0.82
microRNA	0.71

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Adhesion G Protein-coupled Receptor L2

Protein / Defense/immunity Protein / Antibacterial Response Protein / Adhesion G Protein-coupled Receptor L2

Protein / ... / Protease / Adhesion G Protein-coupled Receptor L2

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / Latrophilin Receptor / Adhesion G Protein-coupled Receptor L2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.92   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 136   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.92   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0