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Tbio
NSA2
Ribosome biogenesis protein NSA2 homolog

Protein Summary
Description
Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610426
  • ENSP00000483484
  • ENSG00000164346

Symbol
  • TINP1
  • HCLG1
  • TINP1
  • CDK105
  • HCL-G1
  • HUSSY29
  • HUSSY-29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
disease perturbation
0.9
transcription factor perturbation
0.8
histone modification site profile
0.76
cell type or tissue
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.72   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.72   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NSA2, ribosome biogenesis homolog
VGNC:4107
461806
Macaque
NSA2, ribosome biogenesis homolog
704670
Mouse
MGI:1913883
59050
Rat
RGD:621335
171456
Dog
NSA2, ribosome biogenesis homolog
478102
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NSA2, ribosome biogenesis homolog
Macaque
NSA2, ribosome biogenesis homolog
Mouse
Rat
Dog
NSA2, ribosome biogenesis homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95478-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (464)
1 – 10 of 464
NLE1
Tbio
Novelty: 0.03831535
p_int: 0.999558279
p_ni: 0.000441721
Score: 0.995
Data Source: BioPlex,STRINGDB
ZNF646
Tdark
Family: TF
Novelty: 2.66287151
p_int: 0.997181912
p_ni: 0.00249665
p_wrong: 0.000321438
Score: 0.351
Data Source: BioPlex,STRINGDB
TYW5
Tbio
Novelty: 0.1382439
p_int: 0.997146328
p_ni: 0.002853672
Score: 0.159
Data Source: BioPlex,STRINGDB
GNL2
Tbio
Novelty: 0.01792003
p_int: 0.996615119
p_ni: 0.003384881
Score: 0.999
Data Source: BioPlex,STRINGDB
RRS1
Tbio
Novelty: 0.01643671
p_int: 0.990851211
p_ni: 0.009148789
Score: 0.993
Data Source: BioPlex,STRINGDB
MAGEA9
Tbio
Novelty: 0.07926412
p_int: 0.98390143
p_ni: 0.01609857
Data Source: BioPlex
RPL30
Tbio
Novelty: 0.0134194
p_int: 0.981863818
p_ni: 0.018136182
Score: 0.931
Data Source: BioPlex,STRINGDB
DGCR8
Tbio
Novelty: 0.00271221
p_int: 0.979746911
p_ni: 0.020253089
Data Source: BioPlex
RPL7A
Tbio
Novelty: 0.01674027
p_int: 0.976701432
p_ni: 0.023298568
Score: 0.631
Data Source: BioPlex,STRINGDB
RPL26L1
Tdark
Novelty: 0.75408617
p_int: 0.974699007
p_ni: 0.025300993
Score: 0.889
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  23.72

PubMed score by year
PubTator Score  8.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer