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Tclin
ABCA1
ATP-binding cassette sub-family A member 1

Protein Summary
Description
cAMP-dependent and sulfonylurea-sensitive anion transporter. Involved in the efflux of intracellular cholesterol and phospholipids and their transfer to apoliproteins to form nascent high density lipoproteins/HDLs. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374736
  • ENSP00000363868
  • ENSG00000165029

Symbol
  • ABC1
  • CERP
  • TGD
  • ABC1
  • CERP
  • ABC-1
  • HDLDT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
trait
1
transcription factor perturbation
1
biological process
0.99
virus perturbation
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1822.43   (req: < 5)
Gene RIFs: 536   (req: <= 3)
Antibodies: 529   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1822.43   (req: >= 5)
Gene RIFs: 536   (req: > 3)
Antibodies: 529   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
probucol
chemical structure image
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
23
22
55
1.6
99.7
total cholesterol measurement
8
12
26
3.2
97.4
BMI-adjusted waist-hip ratio
2
3
5
96.7
low density lipoprotein cholesterol measurement
4
7
9
95.8
triglyceride measurement
4
4
7
90.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
55
1.6
99.7
total cholesterol measurement
26
3.2
97.4
BMI-adjusted waist-hip ratio
5
96.7
low density lipoprotein cholesterol measurement
9
95.8
triglyceride measurement
7
90.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily A member 1
VGNC:4595
464630
Macaque
ATP binding cassette subfamily A member 1
716146
Mouse
MGI:99607
11303
Rat
RGD:631344
313210
Dog
ATP binding cassette subfamily A member 1
VGNC:37422
481651
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily A member 1
Macaque
ATP binding cassette subfamily A member 1
Mouse
Rat
Dog
ATP binding cassette subfamily A member 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95477-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
Defective ABCA1 causes Tangier disease
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
HDL assembly
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
Defective ABCA1 causes Tangier disease
Disease
Disorders of transmembrane transporters
HDL assembly
Gene Ontology Terms (60)
Items per page:
10
1 – 10 of 19
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (228)
1 – 10 of 228
APOA1
Tbio
Novelty: 0.0001216
Score: 0.998
Data Source: Reactome,STRINGDB
NR1H2
Tchem
Family: NR
Novelty: 0.01296966
Score: 0.989
Data Source: Reactome,STRINGDB
NR1H3
Tchem
Family: NR
Novelty: 0.00394862
Score: 0.985
Data Source: STRINGDB
PPARA
Tclin
Family: NR
Novelty: 0.00017403
Score: 0.957
Data Source: STRINGDB
FABP1
Tchem
Novelty: 0.00192691
Score: 0.937
Data Source: STRINGDB
PRKACA
Tchem
Family: Kinase
Novelty: 0.03869658
Score: 0.936
Data Source: Reactome,STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.936
Data Source: Reactome,STRINGDB
NCOR1
Tchem
Family: TF
Novelty: 0.0021926
Score: 0.931
Data Source: STRINGDB
GPS2
Tbio
Novelty: 0.00986158
Score: 0.926
Data Source: STRINGDB
RXRB
Tclin
Family: NR
Novelty: 0.01503977
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  1822.43

PubMed score by year
PubTator Score  1228.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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