Tclin ABCA1 ATP-binding cassette sub-family A member 1

Protein Summary

Description

cAMP-dependent and sulfonylurea-sensitive anion transporter. Involved in the efflux of intracellular cholesterol and phospholipids and their transfer to apoliproteins to form nascent high density lipoproteins/HDLs. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95477
• Q5VX33
• Q96S56
• Q96T85
• Q9NQV4
• Q9UN06
• Q9UN07
• Q9UN08
• Q9UN09

Gene Name

• ABCA1

Ensembl ID

• ENST00000374736
• ENSP00000363868
• ENSG00000165029

Symbol

• ABC1
• CERP
• TGD
• ABC1
• CERP
• ABC-1
• HDLDT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
trait	1
transcription factor perturbation	1
biological process	0.99
virus perturbation	0.98

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Atp-binding Cassette Sub-family A Member 1

DTO Classes

Protein / Transporter / Atp-binding Cassette Transporter Family / Abca Subfamily / Atp-binding Cassette Sub-family A Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2035.32   (req: < 5)

Gene RIFs: 668   (req: <= 3)

Antibodies: 529   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2035.32   (req: >= 5)

Gene RIFs: 668   (req: > 3)

Antibodies: 529   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1