Tbio CLDN7 Claudin-7

Protein Summary

Description

Plays a major role in tight junction-specific obliteration of the intercellular space. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]

Uniprot Accession IDs

• O95471
• B2R9X7
• D3DTP0
• Q6IPN3
• Q7Z4Y7
• Q9BVN0
• CLDN-7

Gene Name

• CLDN7

Ensembl ID

• ENST00000360325
• ENSP00000353475
• ENSG00000181885
• ENST00000397317
• ENSP00000396638

Symbol

• CEPTRL2
• CPETRL2
• CLDN-7
• CEPTRL2
• CPETRL2
• Hs.84359
• claudin-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.97
disease	0.94
gene perturbation	0.85
transcription factor perturbation	0.68
tissue	0.67

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Tight Junction / Claudin-7

DTO Classes

Protein / Cell-cell Junction / Tight Junction / Claudin-7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.45   (req: < 5)

Gene RIFs: 98   (req: <= 3)

Antibodies: 457   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.45   (req: >= 5)

Gene RIFs: 98   (req: > 3)

Antibodies: 457   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0