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Tbio
CLDN7
Claudin-7

Protein Summary
Description
Plays a major role in tight junction-specific obliteration of the intercellular space. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360325
  • ENSP00000353475
  • ENSG00000181885
  • ENST00000397317
  • ENSP00000396638

Symbol
  • CEPTRL2
  • CPETRL2
  • CLDN-7
  • CEPTRL2
  • CPETRL2
  • Hs.84359
  • claudin-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
disease
0.94
gene perturbation
0.85
transcription factor perturbation
0.68
tissue
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.11   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 457   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.11   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 457   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
1
1
67.9
vital capacity
1
1
1
32.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
67.9
vital capacity
1
32.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
claudin 7
VGNC:12053
455232
Macaque
claudin 7
714647
Mouse
MGI:1859285
53624
Rat
RGD:68432
65132
Dog
claudin 7
VGNC:53320
489466
Species
Name
OMA
EggNOG
Inparanoid
Chimp
claudin 7
Macaque
claudin 7
Mouse
Rat
Dog
claudin 7
Pathways (9)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (91)
1 – 10 of 91
SCARB1
Tchem
Novelty: 0.00087703
p_int: 0.972977433
p_ni: 0.027022567
Score: 0.714
Data Source: BioPlex,STRINGDB
CLDN12
Tbio
Novelty: 0.04404633
Score: 0.961
Data Source: STRINGDB
CLDN4
Tbio
Novelty: 0.00227337
Score: 0.937
Data Source: STRINGDB
EPCAM
Tbio
Novelty: 0.00042422
Score: 0.936
Data Source: STRINGDB
CLDN3
Tbio
Novelty: 0.00286252
Score: 0.934
Data Source: STRINGDB
CLDN23
Tbio
Novelty: 0.12349944
Score: 0.927
Data Source: STRINGDB
CLDN16
Tbio
Novelty: 0.0092505
Score: 0.916
Data Source: STRINGDB
CLDN6
Tbio
Novelty: 0.01814018
Score: 0.912
Data Source: STRINGDB
CLDN2
Tbio
Novelty: 0.00299455
Score: 0.911
Data Source: STRINGDB
CLDN8
Tbio
Novelty: 0.02218455
Score: 0.911
Data Source: STRINGDB
Publication Statistics
PubMed Score  152.11

PubMed score by year
PubTator Score  118.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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