Tchem SGPL1 Sphingosine-1-phosphate lyase 1

Protein Summary

Description

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.

Uniprot Accession IDs

• O95470
• B2RBD4
• Q7Z732
• Q9ULG8
• Q9UN89
• S1PL

Gene Name

• SGPL1

Ensembl ID

• ENST00000373202
• ENSP00000362298
• ENSG00000166224

Symbol

• KIAA1252
• SPL
• S1PL
• NPHS14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
transcription factor perturbation	0.97
disease perturbation	0.9
co-expressed gene	0.87
virus perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 449.35   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 168   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 449.35   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0