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Tchem
SGPL1
Sphingosine-1-phosphate lyase 1

Protein Summary
Description
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373202
  • ENSP00000362298
  • ENSG00000166224

Symbol
  • KIAA1252
  • SPL
  • S1PL
  • NPHS14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor perturbation
0.97
disease perturbation
0.9
co-expressed gene
0.87
virus perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 353.3   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 353.3   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
60.4
reticulocyte measurement
2
1
2
32.2
reticulocyte count
1
1
1
30.4
lymphocyte count
1
1
1
24.1
monocyte count
1
1
1
24.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
60.4
reticulocyte measurement
2
32.2
reticulocyte count
1
30.4
lymphocyte count
1
24.1
monocyte count
1
24.1
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sphingosine-1-phosphate lyase 1
VGNC:12507
466102
Macaque
sphingosine-1-phosphate lyase 1
716245
Mouse
MGI:1261415
20397
Rat
RGD:628599
286896
Dog
sphingosine-1-phosphate lyase 1
VGNC:46102
489032
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sphingosine-1-phosphate lyase 1
Macaque
sphingosine-1-phosphate lyase 1
Mouse
Rat
Dog
sphingosine-1-phosphate lyase 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95470-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Protein-Protein Interactions (140)
1 – 10 of 140
TRARG1
Tbio
Novelty: 0.07729433
p_int: 0.999997185
p_ni: 0.000002815
Score: 0.207
Data Source: BioPlex,STRINGDB
ANKRD12
Tbio
Novelty: 0.13114331
p_int: 0.999938737
p_ni: 0.000061263
Score: 0.187
Data Source: BioPlex,STRINGDB
TRIM9
Tbio
Family: Enzyme
Novelty: 0.06250762
p_int: 0.999617738
p_ni: 0.000382256
p_wrong: 6e-9
Score: 0.171
Data Source: BioPlex,STRINGDB
HEATR3
Tbio
Novelty: 0.08367436
p_int: 0.998637193
p_ni: 0.001362807
Data Source: BioPlex
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.996612779
p_ni: 0.003387221
Data Source: BioPlex
CACNG5
Tdark
Family: IC
Novelty: 0.52705448
p_int: 0.991052113
p_ni: 0.008947887
Data Source: BioPlex
RAMP1
Tclin
Novelty: 0.00831253
p_int: 0.986885225
p_ni: 0.013114775
Data Source: BioPlex
CYB5B
Tbio
Novelty: 0.09395308
p_int: 0.986885225
p_ni: 0.013114775
Data Source: BioPlex
TNFRSF10C
Tbio
Novelty: 0.0088942
p_int: 0.974567865
p_ni: 0.025430948
p_wrong: 0.000001187
Data Source: BioPlex
AIFM1
Tbio
Novelty: 0.00940088
p_int: 0.970765686
p_ni: 0.029234314
Score: 0.236
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  353.30

PubMed score by year
PubTator Score  2114.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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