Tbio FMNL1 Formin-like protein 1

Protein Summary

Description

May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95466
• D2DGW2
• Q6DKG5
• Q6IBP3
• Q86UH1
• Q8N671
• Q8TDH1
• Q96H10

Gene Name

• FMNL1

Ensembl ID

• ENST00000331495
• ENSP00000329219
• ENSG00000184922

Symbol

• C17orf1
• C17orf1B
• FMNL
• FRL1
• FMNL
• FHOD4
• KW-13
• C17orf1
• C17orf1B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
ligand (protein) perturbation	0.83
cellular component	0.71
transcription factor	0.69
co-expressed gene	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.74   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 155   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.74   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0