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Tbio
GJB6
Gap junction beta-6 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241124
  • ENSP00000241124
  • ENSG00000121742
  • ENST00000356192
  • ENSP00000348521
  • ENST00000400065
  • ENSP00000382938
  • ENST00000400066
  • ENSP00000382939
  • ENST00000636852
  • ENSP00000489698
  • ENST00000643121
  • ENSP00000494468
  • ENST00000643211
  • ENSP00000495841
  • ENST00000644283
  • ENSP00000495320
  • ENST00000644667
  • ENSP00000493621
  • ENST00000647029
  • ENSP00000493834
  • ENST00000647243
  • ENSP00000494733

Symbol
  • ED2
  • EDH
  • HED
  • CX30
  • HED2
  • DFNA3
  • ECTD2
  • DFNA3B
  • DFNB1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
biological term
0.77
phenotype
0.68
disease
0.65
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 888.28   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 888.28   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (7)
Gap junction assembly (R-HSA-190861)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gap junction assembly
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Gap junction assembly
Gap junction trafficking
Gap junction trafficking and regulation
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (74)
1 – 10 of 74
EDA
Tbio
Novelty: 0.00076336
Score: 0.92
Data Source: STRINGDB
CNST
Tdark
Novelty: 0.01678618
Score: 0.785
Data Source: STRINGDB
GJE1
Tdark
Novelty: 0.29459902
Score: 0.747
Data Source: STRINGDB
GPR61
Tbio
Family: GPCR
Novelty: 0.19525282
Score: 0.746
Data Source: STRINGDB
PANX1
Tbio
Family: IC
Novelty: 0.00209499
Score: 0.714
Data Source: STRINGDB
PANX2
Tbio
Family: IC
Novelty: 0.00929804
Score: 0.698
Data Source: STRINGDB
PANX3
Tbio
Family: IC
Novelty: 0.01038516
Score: 0.687
Data Source: STRINGDB
SLC26A4
Tbio
Family: Transporter
Novelty: 0.00186048
Score: 0.682
Data Source: STRINGDB
MYO15A
Tbio
Novelty: 0.02093088
Score: 0.669
Data Source: STRINGDB
TJP1
Tbio
Novelty: 0.0005583
Score: 0.668
Data Source: STRINGDB
Publication Statistics
PubMed Score  888.28

PubMed score by year
PubTator Score  326.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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