GJB6
Gap junction beta-6 protein
Protein Summary
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in s ...more
- ENST00000241124
- ENSP00000241124
- ENSG00000121742
- ENST00000356192
- ENSP00000348521
- ENST00000400065
- ENSP00000382938
- ENST00000400066
- ENSP00000382939
- ENST00000636852
- ENSP00000489698
- ENST00000643121
- ENSP00000494468
- ENST00000643211
- ENSP00000495841
- ENST00000644283
- ENSP00000495320
- ENST00000644667
- ENSP00000493621
- ENST00000647029
- ENSP00000493834
- ENST00000647243
- ENSP00000494733
- ED2
- EDH
- HED
- CX30
- HED2
- DFNA3
- ECTD2
- DFNA3B
- DFNB1B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.83 | ||
biological term | 0.77 | ||
phenotype | 0.68 | ||
disease | 0.65 | ||
protein domain | 0.58 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 792.55 (req: < 5)
Gene RIFs: 99 (req: <= 3)
Antibodies: 227 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 792.55 (req: >= 5)
Gene RIFs: 99 (req: > 3)
Antibodies: 227 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (74)
1 – 10 of 74
EDA
Novelty: 0.00352464
Score: 0.92
Data Source: STRINGDB
CNST
Novelty: 0.10372637
Score: 0.785
Data Source: STRINGDB
GJE1
Novelty: 0.03519662
Score: 0.747
Data Source: STRINGDB
GPR61
Family: GPCR
Novelty: 0.11649666
Score: 0.746
Data Source: STRINGDB
PANX1
Family: IC
Novelty: 0.00159814
Score: 0.714
Data Source: STRINGDB
PANX2
Family: IC
Novelty: 0.00620748
Score: 0.698
Data Source: STRINGDB
PANX3
Family: IC
Novelty: 0.0071997
Score: 0.687
Data Source: STRINGDB
SLC26A4
Family: Transporter
Novelty: 0.00162006
Score: 0.682
Data Source: STRINGDB
MYO15A
Novelty: 0.0148787
Score: 0.669
Data Source: STRINGDB
TJP1
Novelty: 0.00040365
Score: 0.668
Data Source: STRINGDB
Pathways (7)
Reactome (5)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gap junction assembly | ||||
Reactome | Gap junction trafficking | ||||
Reactome | Gap junction trafficking and regulation | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gap junction assembly | ||||
Gap junction trafficking | ||||
Gap junction trafficking and regulation | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
Gene Ontology Terms (15)
Components (5)
Processes (10)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Find similar targets by:
UniProt Keyword
No Header | No Header | ||
|---|---|---|---|
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | gap junction protein beta 6 | VGNC:5062 | 750343 | |||||
Macaque | gap junction protein beta 6 | 704105 | ||||||
Mouse | MGI:107588 | 14623 | ||||||
Rat | RGD:621830 | 84403 | ||||||
Dog | gap junction protein beta 6 | VGNC:41242 | 100688824 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | gap junction protein beta 6 | |||||
Macaque | gap junction protein beta 6 | |||||
Mouse | ||||||
Rat | ||||||
Dog | gap junction protein beta 6 | |||||
Publication Statistics
PubMed Score 792.55
PubMed score by year
PubTator Score 326.68
PubTator score by year