GJB6
Gap junction beta-6 protein
Protein Summary
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in s ...more
- ENST00000241124
- ENSP00000241124
- ENSG00000121742
- ENST00000356192
- ENSP00000348521
- ENST00000400065
- ENSP00000382938
- ENST00000400066
- ENSP00000382939
- ENST00000636852
- ENSP00000489698
- ENST00000643121
- ENSP00000494468
- ENST00000643211
- ENSP00000495841
- ENST00000644283
- ENSP00000495320
- ENST00000644667
- ENSP00000493621
- ENST00000647029
- ENSP00000493834
- ENST00000647243
- ENSP00000494733
- ED2
- EDH
- HED
- CX30
- HED2
- DFNA3
- ECTD2
- DFNA3B
- DFNB1B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.83 | ||
biological term | 0.77 | ||
phenotype | 0.68 | ||
disease | 0.65 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 923.41 (req: < 5)
Gene RIFs: 106 (req: <= 3)
Antibodies: 227 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 923.41 (req: >= 5)
Gene RIFs: 106 (req: > 3)
Antibodies: 227 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0