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Tbio
ADAMTS2
A disintegrin and metalloproteinase with thrombospondin motifs 2

Protein Summary
Description
Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase. This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcrip ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251582
  • ENSP00000251582
  • ENSG00000087116
  • ENST00000274609
  • ENSP00000274609
  • ENST00000639107
  • ENSP00000492365
  • ENSG00000283802
  • ENST00000639986
  • ENSP00000492346

Symbol
  • PCINP
  • PCPNI
  • NPI
  • PNPI
  • PCINP
  • PCPNI
  • PCI-NP
  • PC I-NP
  • ADAM-TS2
  • ADAMTS-2
  • ADAMTS-3
  • EDSDERMS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
PubMedID
0.8
transcription factor perturbation
0.74
transcription factor
0.64
tissue sample
0.62


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.15   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.15   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (125)
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.999351524
p_ni:  0.000648476
Data Source:  BioPlex
TMPRSS11B
Tdark
Family:  Enzyme
Novelty:  1.20690443
p_int:  0.998177247
p_ni:  0.001769055
p_wrong:  0.000053698
Data Source:  BioPlex
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.997562389
p_ni:  0.002437611
Data Source:  BioPlex
ST8SIA4
Tbio
Family:  Enzyme
Novelty:  0.00338436
p_int:  0.997467115
p_ni:  0.002532879
p_wrong:  6e-9
Data Source:  BioPlex
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.996227381
p_ni:  0.003772601
p_wrong:  1.8e-8
Data Source:  BioPlex
SLAMF1
Tbio
Novelty:  0.00112892
p_int:  0.994154883
p_ni:  0.005844974
p_wrong:  1.43e-7
Data Source:  BioPlex
CLEC12A
Tbio
Novelty:  0.01478908
p_int:  0.991124967
p_ni:  0.008585459
p_wrong:  0.000289575
Data Source:  BioPlex
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.988760527
p_ni:  0.010871736
p_wrong:  0.000367737
Data Source:  BioPlex
LYPD4
Tbio
Novelty:  0.00381728
p_int:  0.981293457
p_ni:  0.018706539
p_wrong:  4e-9
Data Source:  BioPlex
CD1B
Tbio
Novelty:  0.00102701
p_int:  0.9737494
p_ni:  0.026250598
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen formation
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
4
4
77.5
body fat distribution
2
1
4
69.3
alkaline phosphatase measurement
1
1
1
46.5
intraocular pressure measurement
1
2
2
45.6
waist circumference
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
4
77.5
body fat distribution
4
69.3
alkaline phosphatase measurement
1
46.5
intraocular pressure measurement
2
45.6
waist circumference
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 2
713532
Mouse
MGI:1347356
216725
Rat
RGD:1565950
287899
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 2
VGNC:37598
481453
Cow
ADAM metallopeptidase with thrombospondin type 1 motif 2
VGNC:25624
282401
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 2
Mouse
Rat
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 2
Cow
ADAM metallopeptidase with thrombospondin type 1 motif 2
Publication Statistics
PubMed Score 114.15
PubMed score by year
PubTator Score 56.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title