Tbio ADAMTS2 A disintegrin and metalloproteinase with thrombospondin motifs 2

Protein Summary

Description

Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase. This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• O95450
• ADAM-TS 2

Gene Name

• ADAMTS2

Ensembl ID

• ENST00000251582
• ENSP00000251582
• ENSG00000087116
• ENST00000274609
• ENSP00000274609
• ENST00000639107
• ENSP00000492365
• ENSG00000283802
• ENST00000639986
• ENSP00000492346

Symbol

• PCINP
• PCPNI
• NPI
• PNPI
• PCINP
• PCPNI
• PCI-NP
• PC I-NP
• ADAM-TS2
• ADAMTS-2
• ADAMTS-3
• EDSDERMS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
PubMedID	0.8
transcription factor perturbation	0.74
transcription factor	0.64
tissue sample	0.62

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Metalloprotease / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 2

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 2

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 2

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 506.21   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 171   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 506.21   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0