Protein Summary
Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid. The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Alternate splicing results in both coding and non-coding variants of this gene. [provided by RefSeq, Jan 2012]
- ENST00000375916
- ENSP00000365081
- ENSG00000204444
- ENST00000375920
- ENSP00000365085
- ENST00000383438
- ENSP00000372930
- ENSG00000206409
- ENST00000400157
- ENSP00000383021
- ENST00000416324
- ENSP00000393581
- ENSG00000224290
- ENST00000422771
- ENSP00000392021
- ENSG00000226215
- ENST00000425177
- ENSP00000403062
- ENSG00000235754
- ENST00000426800
- ENSP00000405730
- ENSG00000227567
- ENST00000430282
- ENSP00000401684
- ENST00000432598
- ENSP00000389591
- ENST00000436931
- ENSP00000394610
- ENSG00000231974
- ENST00000439902
- ENSP00000413446
- ENST00000441436
- ENSP00000398944
- ENST00000443975
- ENSP00000416335
- G3A
- NG20
- G3a
- NG20
- apo-M
- HSPC336
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.9 | ||
histone modification site profile | 0.76 | ||
cellular component | 0.73 | ||
disease | 0.71 | ||
transcription factor perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 261.91 (req: < 5)
Gene RIFs: 92 (req: <= 3)
Antibodies: 486 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 261.91 (req: >= 5)
Gene RIFs: 92 (req: > 3)
Antibodies: 486 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (112)
CT45A2
Novelty: 0.98875916
p_int: 0.999938361
p_ni: 0.000061638
Score: 0.689
Data Source: BioPlex,STRINGDB
USP16
Family: Enzyme
Novelty: 0.13211126
p_int: 0.999711318
p_ni: 0.000288637
p_wrong: 4.5e-8
Score: 0.345
Data Source: BioPlex,STRINGDB
SEC11C
Family: Enzyme
Novelty: 0.19577003
p_int: 0.996747856
p_ni: 0.000111016
p_wrong: 0.003141128
Score: 0.188
Data Source: BioPlex,STRINGDB
CNTNAP3
Novelty: 0.22791524
p_int: 0.832248757
p_ni: 0.167751014
p_wrong: 2.28e-7
Score: 0.177
Data Source: BioPlex,STRINGDB
CDYL
Family: Epigenetic
Novelty: 0.03367841
p_int: 0.811884855
p_ni: 0.188114017
p_wrong: 0.000001128
Score: 0.205
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (9)
Reactome (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of fat-soluble vitamins | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
Metabolism | ||||
Metabolism of fat-soluble vitamins | ||||
Metabolism of vitamins and cofactors | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (3)
Components (6)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (602)
Items per page:
1 – 5 of 602
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
1 | 3 | 0 | 3 | 96.3 | ||||||
1 | 3 | 0 | 3 | 96.3 | ||||||
1 | 3 | 0 | 3 | 96.3 | ||||||
1 | 3 | 0 | 3 | 96.3 | ||||||
1 | 3 | 0 | 3 | 96.3 | ||||||
Items per page:
1 – 5 of 602
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 3 | 96.3 | |||||
0 | 3 | 96.3 | |||||
0 | 3 | 96.3 | |||||
0 | 3 | 96.3 | |||||
0 | 3 | 96.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | apolipoprotein M | 715848 | ||||||
Mouse | MGI:1930124 | 55938 | ||||||
Rat | RGD:620773 | 55939 | ||||||
Dog | apolipoprotein M | VGNC:38008 | 474843 | |||||
Horse | apolipoprotein M | VGNC:15424 | 100050362 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | apolipoprotein M | |||||
Mouse | ||||||
Rat | ||||||
Dog | apolipoprotein M | |||||
Horse | apolipoprotein M | |||||
Publication Statistics
PubMed Score 261.91
PubMed score by year
PubTator Score 131.85
PubTator score by year
Related Publications
Text Mined References (113)
GeneRif Annotations (92)
Items per page:
0 of 0
PMID | Year | Title |
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