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Tchem
SLC34A2
Sodium-dependent phosphate transport protein 2B

Protein Summary
Description
May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli. The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382051
  • ENSP00000371483
  • ENSG00000157765
  • ENST00000503434
  • ENSP00000423021
  • ENST00000504570
  • ENSP00000425501
  • ENST00000645788
  • ENSP00000494094

Symbol
  • NPTIIb
  • NAPI-3B
  • NAPI-IIb
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
gene perturbation
0.83
virus perturbation
0.83
cell type or tissue
0.7
tissue sample
0.62


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.73   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.73   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL4159390
Rendered image for CHEMBL4159390
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
8.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
8.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 34 member 2
VGNC:7722
471424
Macaque
solute carrier family 34 member 2
694217
Mouse
MGI:1342284
20531
Rat
RGD:620889
84395
Dog
solute carrier family 34 member 2
VGNC:46359
488850
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 34 member 2
Macaque
solute carrier family 34 member 2
Mouse
Rat
Dog
solute carrier family 34 member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95436-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) (R-HSA-5619045)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
Reactome
Disease
Reactome
Diseases associated with surfactant metabolism
Reactome
Diseases of metabolism
Reactome
Disorders of transmembrane transporters
Name
Explore in Pharos
Explore in Source
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
Disease
Diseases associated with surfactant metabolism
Diseases of metabolism
Disorders of transmembrane transporters
Protein-Protein Interactions (58)
1 – 10 of 58
PCDH10
Tbio
Novelty:  0.01058382
p_int:  0.999980591
p_ni:  0.000019408
Score:  0.189
Data Source:  BioPlex,STRINGDB
KRIT1
Tbio
Novelty:  0.00454953
p_int:  0.999773928
p_ni:  0.000226064
p_wrong:  8e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
ENDOD1
Tdark
Family:  Enzyme
Novelty:  0.26430864
p_int:  0.999456225
p_ni:  0.000543774
p_wrong:  1e-9
Score:  0.264
Data Source:  BioPlex,STRINGDB
ZDHHC18
Tdark
Family:  Enzyme
Novelty:  0.44878853
p_int:  0.99650613
p_ni:  0.003493843
p_wrong:  2.8e-8
Data Source:  BioPlex
LMTK2
Tbio
Family:  Kinase
Novelty:  0.02138451
p_int:  0.993978166
p_ni:  0.000029314
p_wrong:  0.00599252
Score:  0.319
Data Source:  BioPlex,STRINGDB
LINGO2
Tbio
Novelty:  0.06112205
p_int:  0.99176725
p_ni:  0.007013712
p_wrong:  0.001219038
Score:  0.173
Data Source:  BioPlex,STRINGDB
ATP6V0A1
Tbio
Family:  Enzyme
Novelty:  0.02009317
p_int:  0.980407477
p_ni:  0.019592523
Score:  0.179
Data Source:  BioPlex,STRINGDB
LNPK
Tbio
Novelty:  0.07736762
p_int:  0.976417763
p_ni:  0.023582237
Data Source:  BioPlex
ATP11C
Tbio
Family:  Transporter
Novelty:  0.05441047
p_int:  0.965238578
p_ni:  0.034761422
Score:  0.188
Data Source:  BioPlex,STRINGDB
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.953688355
p_ni:  0.046311645
Score:  0.231
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  184.73

PubMed score by year
PubTator Score  81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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