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Tbio
AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

Protein Summary
Description
Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216479
  • ENSP00000216479
  • ENSG00000100591
  • ENST00000535854
  • ENSP00000440108

Symbol
  • C14orf3
  • p38
  • AHA1
  • hAha1
  • C14orf3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
histone modification site profile
0.94
interacting protein
0.82
kinase perturbation
0.81
protein complex
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.44   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 781   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.44   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 781   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0