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Tbio
AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

Protein Summary
Description
Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216479
  • ENSP00000216479
  • ENSG00000100591
  • ENST00000535854
  • ENSP00000440108

Symbol
  • C14orf3
  • p38
  • AHA1
  • hAha1
  • C14orf3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
histone modification site profile
0.94
interacting protein
0.82
kinase perturbation
0.81
protein complex
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.34   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 781   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.34   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 781   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activator of HSP90 ATPase activity 1
VGNC:10302
453070
Macaque
activator of HSP90 ATPase activity 1
706547
Mouse
MGI:2387603
217737
Rat
RGD:1589285
681996
Dog
activator of HSP90 ATPase activity 1
VGNC:37730
480402
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activator of HSP90 ATPase activity 1
Macaque
activator of HSP90 ATPase activity 1
Mouse
Rat
Dog
activator of HSP90 ATPase activity 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95433-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
WikiPathways
T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
WikiPathways
Interferon type I signaling pathways
WikiPathways
IL-2 Signaling Pathway
WikiPathways
Notch Signaling Pathway
Name
Explore in Pharos
Explore in Source
T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
Interferon type I signaling pathways
IL-2 Signaling Pathway
Notch Signaling Pathway
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (133)
1 – 10 of 133
HSP90AA1
Tchem
Novelty: 0.00016774
Score: 0.996
Data Source: STRINGDB
STIP1
Tbio
Novelty: 0.00590952
Score: 0.995
Data Source: STRINGDB
HSP90AB1
Tchem
Novelty: 0.00907961
Score: 0.98
Data Source: STRINGDB
PTGES3
Tbio
Family: Enzyme
Novelty: 0.0082783
Score: 0.964
Data Source: STRINGDB
SUGT1
Tbio
Novelty: 0.1042721
Score: 0.931
Data Source: STRINGDB
HSPA4
Tbio
Novelty: 0.00009122
Score: 0.914
Data Source: STRINGDB
TRAP1
Tchem
Novelty: 0.03344189
Score: 0.9
Data Source: STRINGDB
PPID
Tchem
Family: Enzyme
Novelty: 0.01068886
Score: 0.866
Data Source: STRINGDB
CDC37
Tbio
Novelty: 0.03730196
Score: 0.856
Data Source: STRINGDB
CACYBP
Tbio
Novelty: 0.02207811
Score: 0.853
Data Source: STRINGDB
Publication Statistics
PubMed Score  80.34

PubMed score by year
PubTator Score  46.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer