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Tbio
BAG4
BAG family molecular chaperone regulator 4

Protein Summary
Description
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis whi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287322
  • ENSP00000287322
  • ENSG00000156735
  • ENST00000432471
  • ENSP00000393298

Symbol
  • SODD
  • SODD
  • BAG-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
kinase perturbation
0.84
interacting protein
0.82
histone modification site profile
0.8
cell type or tissue
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.98   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 381   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.98   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL2 associated athanogene 4
VGNC:2460
464116
Macaque
BCL2 associated athanogene 4
703953
Mouse
MGI:1914634
67384
Dog
BCL2 associated athanogene 4
VGNC:38366
607954
Horse
BCL2 associated athanogene 4
VGNC:15754
100057730
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL2 associated athanogene 4
Macaque
BCL2 associated athanogene 4
Mouse
Dog
BCL2 associated athanogene 4
Horse
BCL2 associated athanogene 4
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95429-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (30)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Death Receptor Signalling
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Death Receptor Signalling
Disease
Protein-Protein Interactions (122)
1 – 10 of 122
DCP1B
Tdark
Novelty: 0.36605365
p_int: 0.999986557
p_ni: 0.000013443
Score: 0.776
Data Source: BioPlex,STRINGDB
C3orf38
Tdark
Novelty: 2.10467478
p_int: 0.999986261
p_ni: 0.000013507
p_wrong: 2.31e-7
Score: 0.219
Data Source: BioPlex,STRINGDB
HSF1
Tchem
Family: TF
Novelty: 0.00450276
p_int: 0.99997066
p_ni: 0.000029311
p_wrong: 2.9e-8
Score: 0.626
Data Source: BioPlex,STRINGDB
DNAJC13
Tbio
Novelty: 0.03251995
p_int: 0.999298346
p_ni: 0.000701654
Score: 0.161
Data Source: BioPlex,STRINGDB
EDC3
Tbio
Novelty: 0.02077346
p_int: 0.999228836
p_ni: 0.000771164
Score: 0.685
Data Source: BioPlex,STRINGDB
BCORL1
Tbio
Novelty: 0.03899646
p_int: 0.998712074
p_ni: 0.000980801
p_wrong: 0.000307125
Score: 0.341
Data Source: BioPlex,STRINGDB
KLHL18
Tdark
Novelty: 0.52915213
p_int: 0.997871834
p_ni: 0.002128166
Data Source: BioPlex
HSF2
Tbio
Family: TF
Novelty: 0.06458223
p_int: 0.995909866
p_ni: 0.000081042
p_wrong: 0.004009092
Score: 0.314
Data Source: BioPlex,STRINGDB
ZNF318
Tbio
Novelty: 0.03072403
p_int: 0.99314536
p_ni: 0.006854627
p_wrong: 1.3e-8
Data Source: BioPlex
DCP1A
Tbio
Novelty: 0.02038933
p_int: 0.982357097
p_ni: 0.017642903
Score: 0.752
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  39.98

PubMed score by year
PubTator Score  19.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer