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Tbio
SVIL
Supervillin

Protein Summary
Description
Isoform 1: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). Isoform 2: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or se ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355867
  • ENSP00000348128
  • ENSG00000197321
  • ENST00000375398
  • ENSP00000364547
  • ENST00000375400
  • ENSP00000364549
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.98
drug perturbation
0.96
trait
0.93
virus perturbation
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.38   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.38   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
1
2
40.7
creatinine measurement
1
1
1
39.6
1
1
0
1.1
33.1
platelet reactivity measurement
1
1
1
15.8
bone fracture
1
1
0
2.1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
40.7
creatinine measurement
1
39.6
0
1.1
33.1
platelet reactivity measurement
1
15.8
bone fracture
0
2.1
15.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
supervillin
VGNC:5797
450874
Macaque
supervillin
695267
Mouse
MGI:2147319
225115
Rat
RGD:1306354
361256
Dog
supervillin
VGNC:47007
477965
Species
Name
OMA
EggNOG
Inparanoid
Chimp
supervillin
Macaque
supervillin
Mouse
Rat
Dog
supervillin
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95425-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (2)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Coregulation of Androgen receptor activity
PathwayCommons: netpath
AndrogenReceptor
Name
Explore in Pharos
Explore in Source
Coregulation of Androgen receptor activity
AndrogenReceptor
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (86)
1 – 10 of 86
TMOD3
Tbio
Novelty:  0.04744699
p_int:  0.999989469
p_ni:  3.18e-7
p_wrong:  0.000010213
Score:  0.301
Data Source:  BioPlex,STRINGDB
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  0.994305957
p_ni:  0.00000185
p_wrong:  0.005692193
Score:  0.203
Data Source:  BioPlex,STRINGDB
VCL
Tbio
Novelty:  0.00043107
Score:  0.864
Data Source:  STRINGDB
FLOT2
Tbio
Novelty:  0.00727325
Score:  0.846
Data Source:  STRINGDB
COA7
Tbio
Family:  Enzyme
Novelty:  0.08512811
Score:  0.819
Data Source:  STRINGDB
FLOT1
Tbio
Novelty:  0.00504569
Score:  0.81
Data Source:  STRINGDB
SCAF4
Tbio
Novelty:  0.08174395
Score:  0.809
Data Source:  STRINGDB
ACTB
Tbio
Novelty:  0.00006048
Score:  0.803
Data Source:  STRINGDB
CTTN
Tbio
Novelty:  0.0017962
Score:  0.795
Data Source:  STRINGDB
KIF14
Tbio
Novelty:  0.02313641
Score:  0.786
Data Source:  STRINGDB
Publication Statistics
PubMed Score  38.38

PubMed score by year
PubTator Score  23.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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