Protein Summary
Isoform 1: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). Isoform 2: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or se ...more
- ENST00000355867
- ENSP00000348128
- ENSG00000197321
- ENST00000375398
- ENSP00000364547
- ENST00000375400
- ENSP00000364549
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
kinase perturbation | 0.98 | ||
drug perturbation | 0.96 | ||
trait | 0.93 | ||
virus perturbation | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.38 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 107 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.38 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 107 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (86)
TMOD3
Novelty: 0.04744699
p_int: 0.999989469
p_ni: 3.18e-7
p_wrong: 0.000010213
Score: 0.301
Data Source: BioPlex,STRINGDB
CAPZA2
Novelty: 0.14014918
p_int: 0.994305957
p_ni: 0.00000185
p_wrong: 0.005692193
Score: 0.203
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
PathwayCommons (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: pid | Coregulation of Androgen receptor activity | ||||
PathwayCommons: netpath | AndrogenReceptor | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Coregulation of Androgen receptor activity | ||||
AndrogenReceptor | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (1)
Components (12)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 2 | 1 | 2 | 40.7 | |||||
creatinine measurement | 1 | 1 | 1 | 39.6 | |||||
1 | 1 | 0 | 1.1 | 33.1 | |||||
platelet reactivity measurement | 1 | 1 | 1 | 15.8 | |||||
1 | 1 | 0 | 2.1 | 15.8 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 2 | 40.7 | |||||
creatinine measurement | 1 | 39.6 | |||||
0 | 1.1 | 33.1 | |||||
platelet reactivity measurement | 1 | 15.8 | |||||
0 | 2.1 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | supervillin | VGNC:5797 | 450874 | |||||
Macaque | supervillin | 695267 | ||||||
Mouse | MGI:2147319 | 225115 | ||||||
Rat | RGD:1306354 | 361256 | ||||||
Dog | supervillin | VGNC:47007 | 477965 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | supervillin | |||||
Macaque | supervillin | |||||
Mouse | ||||||
Rat | ||||||
Dog | supervillin | |||||
Publication Statistics
PubMed Score 38.38
PubMed score by year
PubTator Score 23.38
PubTator score by year
Related Publications
Text Mined References (36)
GeneRif Annotations (16)
Items per page:
0 of 0
PMID | Year | Title |
|---|