Tbio SVIL Supervillin

Protein Summary

Description

Isoform 1: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). Isoform 2: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• O95425
• D3DRW9
• M1J557
• O60611
• O60612
• Q5VZK5
• Q5VZK6
• Q9H1R7

Gene Name

• SVIL

Ensembl ID

• ENST00000355867
• ENSP00000348128
• ENSG00000197321
• ENST00000375398
• ENSP00000364547
• ENST00000375400
• ENSP00000364549

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
kinase perturbation	0.98
drug perturbation	0.96
trait	0.93
virus perturbation	0.9

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.38   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.38   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	2	1	2		40.7
creatinine measurement	EFO_0004518	1	1	1		39.6
dilated cardiomyopathy	EFO_0000407	1	1	0	1.1	33.1
platelet reactivity measurement	EFO_0004985	1	1	1		15.8
bone fracture	EFO_0003931	1	1	0	2.1	15.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	2		40.7
creatinine measurement	EFO_0004518	1		39.6
dilated cardiomyopathy	EFO_0000407	0	1.1	33.1
platelet reactivity measurement	EFO_0004985	1		15.8
bone fracture	EFO_0003931	0	2.1	15.8

Reset Zoom  Beta Count   Odds Ratio

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	supervillin	VGNC:5797	450874
Macaque	supervillin		695267
Mouse	supervillin	MGI:2147319	225115
Rat	supervillin	RGD:1306354	361256
Dog	supervillin	VGNC:47007	477965

Species	Name	OMA	EggNOG	Inparanoid
Chimp	supervillin
Macaque	supervillin
Mouse	supervillin
Rat	supervillin
Dog	supervillin

Protein Structure (2 Structures, 1 AlphaFold Model)

tutorial

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95425-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (2)

PathwayCommons (2)

Find Similar Targets

Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: pid	Coregulation of Androgen receptor activity	61 targets	PathwayCommons: pid
PathwayCommons: netpath	AndrogenReceptor	164 targets	PathwayCommons: netpath

Name	Explore in Pharos	Explore in Source
Coregulation of Androgen receptor activity	61 targets	PathwayCommons: pid
AndrogenReceptor	164 targets	PathwayCommons: netpath

Gene Ontology Terms (16)

Functions (1)

Components (12)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
actin filament binding	Inferred from Direct Assay (IDA)	UniProtKB

Protein-Protein Interactions (86)

Explore Interacting Targets

1 – 10 of 86

• See Interactions on String-DB

TMOD3

Tbio

Novelty:  0.04744699

p_int:  0.999989469

p_ni:  3.18e-7

p_wrong:  0.000010213

Score:  0.301

Data Source:  BioPlex,STRINGDB

CAPZA2

Tbio

Novelty:  0.14014918

p_int:  0.994305957

p_ni:  0.00000185

p_wrong:  0.005692193

Score:  0.203

Data Source:  BioPlex,STRINGDB

VCL

Tbio

Novelty:  0.00043107

Score:  0.864

Data Source:  STRINGDB

FLOT2

Tbio

Novelty:  0.00727325

Score:  0.846

Data Source:  STRINGDB

COA7

Tbio

Family:  Enzyme

Novelty:  0.08512811

Score:  0.819

Data Source:  STRINGDB

FLOT1

Tbio

Novelty:  0.00504569

Score:  0.81

Data Source:  STRINGDB

SCAF4

Tbio

Novelty:  0.08174395

Score:  0.809

Data Source:  STRINGDB

ACTB

Tbio

Novelty:  0.00006048

Score:  0.803

Data Source:  STRINGDB

CTTN

Tbio

Novelty:  0.0017962

Score:  0.795

Data Source:  STRINGDB

KIF14

Tbio

Novelty:  0.02313641

Score:  0.786

Data Source:  STRINGDB

Publication Statistics

PubMed Score  38.38

PubMed score by year

Reset Zoom

PubTator Score  23.38

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Actin-binding
Alternative splicing
Calcium
Cell junction
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton

GWAS Trait Find Similar Targets

No Header	No Header
bone fracture
creatinine measurement
dilated cardiomyopathy
glomerular filtration rate
platelet count
platelet crit
platelet reactivity measurement
thrombus formation measurement

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
homeostasis/metabolism phenotype