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Tbio
BRI3
Brain protein I3

Protein Summary
Description
Participates in tumor necrosis factor-alpha (TNF)-induced cell death (PubMed:14592447). May be a target of Wnt/beta-catenin signaling in the liver (PubMed:20538055).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297290
  • ENSP00000297290
  • ENSG00000164713

Symbol
  • I3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
gene perturbation
0.76
tissue sample
0.74
small molecule perturbation
0.73
virus perturbation
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.41   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.41   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
7
4
7
98.7
testosterone measurement
5
5
5
97
4
2
0
1.1
91.4
urate measurement
2
2
2
80.6
lymphocyte percentage of leukocytes
1
1
1
72.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
7
98.7
testosterone measurement
5
97
0
1.1
91.4
urate measurement
2
80.6
lymphocyte percentage of leukocytes
1
72.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
brain protein I3
VGNC:7352
463558
Macaque
brain protein I3
706525
Mouse
MGI:1933174
55950
Rat
RGD:1309187
304284
Dog
brain protein I3
VGNC:38525
608902
Species
Name
OMA
EggNOG
Inparanoid
Chimp
brain protein I3
Macaque
brain protein I3
Mouse
Rat
Dog
brain protein I3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95415-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Protein-Protein Interactions (56)
1 – 10 of 56
RAP1B
Tbio
Family:  Enzyme
Novelty:  0.00627538
Score:  0.91
Data Source:  STRINGDB
ABCA13
Tbio
Family:  Transporter
Novelty:  0.03723754
Score:  0.909
Data Source:  STRINGDB
CD63
Tchem
Novelty:  0.00072515
Score:  0.908
Data Source:  STRINGDB
VAMP8
Tbio
Novelty:  0.01083228
Score:  0.906
Data Source:  STRINGDB
ARL8A
Tbio
Family:  Enzyme
Novelty:  0.12499089
Score:  0.904
Data Source:  STRINGDB
CD68
Tbio
Novelty:  0.00017859
Score:  0.903
Data Source:  STRINGDB
RAB5C
Tbio
Family:  Enzyme
Novelty:  0.02952779
Score:  0.903
Data Source:  STRINGDB
NCSTN
Tbio
Novelty:  0.00453935
Score:  0.902
Data Source:  STRINGDB
TMEM179B
Tdark
Novelty:  19.38461538
Score:  0.902
Data Source:  STRINGDB
DDOST
Tchem
Family:  Enzyme
Novelty:  0.01797594
Score:  0.902
Data Source:  STRINGDB
Publication Statistics
PubMed Score  49.41

PubMed score by year
PubTator Score  113.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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