Tbio TNFRSF6B Tumor necrosis factor receptor superfamily member 6B

Protein Summary

Description

Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• O95407

Gene Name

• TNFRSF6B

Ensembl ID

• ENST00000369996
• ENSP00000359013
• ENSG00000243509

Symbol

• DCR3
• TR6
• M68
• TR6
• DCR3
• M68E
• DJ583P15.1.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.82
disease	0.79
phenotype	0.7
tissue sample	0.58
tissue	0.47

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 383.85   (req: < 5)

Gene RIFs: 127   (req: <= 3)

Antibodies: 284   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 383.85   (req: >= 5)

Gene RIFs: 127   (req: > 3)

Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0